Academic Journal
The one-carbon-cycle and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in recurrent major depressive disorder:influence of antidepressant use and depressive state?
| العنوان: | The one-carbon-cycle and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in recurrent major depressive disorder:influence of antidepressant use and depressive state? |
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| المؤلفون: | Lok, A, Mocking, R J T, Assies, J, Koeter, M W, Bockting, C L, de Vries, G J, Visser, I, Derks, E M, Kayser, M, Schene, A H |
| المصدر: | Lok , A , Mocking , R J T , Assies , J , Koeter , M W , Bockting , C L , de Vries , G J , Visser , I , Derks , E M , Kayser , M & Schene , A H 2014 , ' The one-carbon-cycle and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in recurrent major depressive disorder : influence of antidepressant use and depressive state? ' , Journal of Affective Disorders , vol. 166 , pp. 115-123 . https://doi.org/10.1016/j.jad.2014.04.048 |
| سنة النشر: | 2014 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | Depressive disorder, Methylenetetrahydrofolate Reductase, (NADPH2)/genetics, Folate, Homocysteine, Vitamin B6, PLASMA HOMOCYSTEINE LEVELS, THERMOLABILE VARIANT, FOLATE STATUS, OLDER WOMEN, U.S. ADULTS, VITAMIN-B-12, ASSOCIATION, SYMPTOMS, HEALTH, METABOLISM |
| الوصف: | BACKGROUND: An important biological factor suggested in the pathophysiology of (recurrent) Major Depressive Disorder (MDD) concerns a polymorphism in a gene encoding for the MTHFR-enzyme of the one-carbon (1-C)-metabolism. Integratively investigating key 1-C-components (folate, homocysteine, vitamin B6 and B12), including the possible effects of antidepressant medication and depressive state, could provide more insight in the possible association between the MTHFR-polymorphism and recurrent MDD. METHODS: We compared the MTHFR C677T-polymorphism together with the key 1-C-components in clinically ascertained patients with recurrent MDD (n=137) to age- and gender-matched healthy controls (n=73). RESULTS: First, patients had lower folate (t=2.25; p=.025) as compared to controls; a difference that resolved after correction for demographics (t=1.22; p=.223). Second, patients that were depressed during sampling had lower vitamin B6 (t=-2.070; p=.038) and higher homocysteine (t=2.404; p=.016) compared to those in remission. Finally, current use of antidepressants had no influence on the 1-C-components. CONCLUSIONS: Despite investigation of a specific recurrently depressed patient population, we found no clear associations with the 1-C-cycle, except for higher homocysteine and lower vitamin B6 during the depressed state. This suggests that 1-C-cycle alterations in MDD are state-associated, possibly resulting from high levels of acute (psychological) stress, and may provide a treatment target to reduce cardiovascular risk in this population. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1016/j.jad.2014.04.048 |
| الاتاحة: | https://hdl.handle.net/11370/fc7b8043-4042-4d5c-a81e-39b600aebdbb https://research.rug.nl/en/publications/fc7b8043-4042-4d5c-a81e-39b600aebdbb https://doi.org/10.1016/j.jad.2014.04.048 https://pure.rug.nl/ws/files/65355309/1_s2.0_S0165032714002420_main.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.2029CC6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jad.2014.04.048 |
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