Book
Ultrastructural and Immunohistochemical Diagnosis of a Neonatal Herpes Simplex Virus Infection Presenting as Fulminant Hepatitis: A Case Report
| العنوان: | Ultrastructural and Immunohistochemical Diagnosis of a Neonatal Herpes Simplex Virus Infection Presenting as Fulminant Hepatitis: A Case Report |
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| المؤلفون: | Papa V, Salfi NCM, Costa R, Bettocchi I, Ricci E, Cordelli DM, Locatelli F, Caramelli F, Cenacchi G. |
| المساهمون: | G. Donelli, V. Papa, N. Salfi, R. Costa, I. Bettocchi, E. Ricci, D. Cordelli, F. Locatelli, F. Caramelli, G. Cenacchi |
| بيانات النشر: | Springer |
| سنة النشر: | 2022 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Electron microscopy, Hepatiti, Herpes simplex, Postmorten diagnosi, Virus, Settore MED/39 - Neuropsichiatria Infantile |
| الوصف: | TORCH (Toxoplasmosis, Rubella, Cytomegalovirus, Herpes Simplex Virus and Syphilis) infections are a major cause of intrauterine and perinatal infections with associated morbidity and mortality. Neonatal Herpes Simplex Virus infection caused by an enveloped, double-stranded DNA virus of the Herpesviridae family is devastating and fatal. Herpes Viruses are not hepatotropic but may rarely cause hepatitis. Most cases of HSV hepatitis rapidly progress to fulminant hepatic failure and often fatal before the diagnosis or transplantation. Nowadays, despite the availability of antiviral treatment (acyclovir), the outcome remains poor because of late identification of hepatic Herpes Simplex Virus (HSV) infection. We report a male neonate suspected with a metabolic/mitochondrial disease and multi-organ involvement but who developed a fulminant hepatic failure and disseminated coagulopathy secondary to HSV type 1 (HSV-1) infection. The postmortem diagnosis was performed demonstrating HSV-1 in liver tissue by transmission electron microscopy and by retrospective detection of HSV specific antigens by immunohistochemistry. |
| نوع الوثيقة: | book part |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/isbn/978-3-031-01994-4; info:eu-repo/semantics/altIdentifier/isbn/978-3-031-01995-1; info:eu-repo/semantics/altIdentifier/pmid/34302289; ispartofbook:Advances in Microbiology, Infectious Diseases and Public Health; volume:1369; firstpage:93; lastpage:100; numberofpages:8; serie:ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY; alleditors:G. Donelli; http://hdl.handle.net/2434/897101; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85129996735 |
| DOI: | 10.1007/5584_2021_659 |
| الاتاحة: | http://hdl.handle.net/2434/897101 https://doi.org/10.1007/5584_2021_659 |
| رقم الانضمام: | edsbas.1FE32778 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/5584_2021_659 |
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