Academic Journal
Baseline procalcitonin as a predictor of bacterial infection and clinical outcomes in COVID-19: A case-control study.
| العنوان: | Baseline procalcitonin as a predictor of bacterial infection and clinical outcomes in COVID-19: A case-control study. |
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| المؤلفون: | Natalie J Atallah, Hailey M Warren, Matthew B Roberts, Ramy H Elshaboury, Monique R Bidell, Ronak G Gandhi, Meagan Adamsick, Maryam K Ibrahim, Rupali Sood, Savo Bou Zein Eddine, Matthew J Cobler-Lichter, Natalie J Alexander, Kyle D Timmer, Christine J Atallah, Adam L Viens, Vahe S Panossian, Allison K Scherer, Teddie Proctor, Sherrie Smartt, Alyssa R Letourneau, Molly L Paras, Sascha Johannes, Jan Wiemer, Michael K Mansour |
| المصدر: | PLoS ONE, Vol 17, Iss 1, p e0262342 (2022) |
| بيانات النشر: | Public Library of Science (PLoS) |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Purpose Coronavirus disease-2019 (COVID-19) is associated with a wide spectrum of clinical symptoms including acute respiratory failure. Biomarkers that can predict outcomes in patients with COVID-19 can assist with patient management. The aim of this study is to evaluate whether procalcitonin (PCT) can predict clinical outcome and bacterial superinfection in patients infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Methods Adult patients diagnosed with SARS-CoV-2 by nasopharyngeal PCR who were admitted to a tertiary care center in Boston, MA with SARS-CoV-2 infection between March 17 and April 30, 2020 with a baseline PCT value were studied. Patients who were presumed positive for SARS-CoV-2, who lacked PCT levels, or who had a positive urinalysis with negative cultures were excluded. Demographics, clinical and laboratory data were extracted from the electronic medical records. Results 324 patient charts were reviewed and grouped by clinical and microbiologic outcomes by day 28. Baseline PCT levels were significantly higher for patients who were treated for true bacteremia (p = 0.0005) and bacterial pneumonia (p = 0.00077) compared with the non-bacterial infection group. Baseline PCT positively correlated with the NIAID ordinal scale and survival over time. When compared to other inflammatory biomarkers, PCT showed superiority in predicting bacteremia. Conclusions Baseline PCT levels are associated with outcome and bacterial superinfection in patients hospitalized with SARS-CoV-2. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | https://doi.org/10.1371/journal.pone.0262342; https://doaj.org/toc/1932-6203; https://doaj.org/article/40caa49471e94ffe9ec4277313441df5 |
| DOI: | 10.1371/journal.pone.0262342 |
| الاتاحة: | https://doi.org/10.1371/journal.pone.0262342 https://doaj.org/article/40caa49471e94ffe9ec4277313441df5 |
| رقم الانضمام: | edsbas.1FC1FFE2 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0262342 |