Academic Journal
Population replacement gene drive characteristics for malaria elimination in a range of seasonal transmission settings: a modelling study
| العنوان: | Population replacement gene drive characteristics for malaria elimination in a range of seasonal transmission settings: a modelling study |
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| المؤلفون: | Shirley Leung, Nikolai Windbichler, Edward A Wenger, Caitlin A Bever, Prashanth Selvaraj |
| المصدر: | Malaria Journal, Vol 21, Iss 1, Pp 1-20 (2022) |
| بيانات النشر: | BMC |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216 |
| الوصف: | Background Gene drives are a genetic engineering method where a suite of genes is inherited at higher than Mendelian rates and has been proposed as a promising new vector control strategy to reinvigorate the fight against malaria in sub-Saharan Africa. Methods Using an agent-based model of malaria transmission with vector genetics, the impacts of releasing population-replacement gene drive mosquitoes on malaria transmission are examined and the population replacement gene drive system parameters required to achieve local elimination within a spatially-resolved, seasonal Sahelian setting are quantified. The performance of two different gene drive systems—“classic” and “integral”—are evaluated. Various transmission regimes (low, moderate, and high—corresponding to annual entomological inoculation rates of 10, 30, and 80 infectious bites per person) and other simultaneous interventions, including deployment of insecticide-treated nets (ITNs) and passive healthcare-seeking, are also simulated. Results Local elimination probabilities decreased with pre-existing population target site resistance frequency, increased with transmission-blocking effectiveness of the introduced antiparasitic gene and drive efficiency, and were context dependent with respect to fitness costs associated with the introduced gene. Of the four parameters, transmission-blocking effectiveness may be the most important to focus on for improvements to future gene drive strains because a single release of classic gene drive mosquitoes is likely to locally eliminate malaria in low to moderate transmission settings only when transmission-blocking effectiveness is very high (above ~ 80–90%). However, simultaneously deploying ITNs and releasing integral rather than classic gene drive mosquitoes significantly boosts elimination probabilities, such that elimination remains highly likely in low to moderate transmission regimes down to transmission-blocking effectiveness values as low as ~ 50% and in high transmission regimes with ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1475-2875 |
| Relation: | https://doi.org/10.1186/s12936-022-04242-2; https://doaj.org/toc/1475-2875; https://doaj.org/article/341bf57c7c7f456391729c0a16f51a5f |
| DOI: | 10.1186/s12936-022-04242-2 |
| الاتاحة: | https://doi.org/10.1186/s12936-022-04242-2 https://doaj.org/article/341bf57c7c7f456391729c0a16f51a5f |
| رقم الانضمام: | edsbas.1FA7A04 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14752875 |
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| DOI: | 10.1186/s12936-022-04242-2 |