التفاصيل البيبلوغرافية
| العنوان: |
Three new indole diterpenoids from Aspergillus aculeatus KKU-CT2 |
| المؤلفون: |
Boonyanoot Chaiyosang (820499), Kwanjai Kanokmedhakul (536850), Natanong Yodsing (10931857), Sophon Boonlue (619134), Jian-Xiong Yang (10016100), Yan Alexander Wang (1819240), Raymond J. Andersen (155984), Jantana Yahuafai (4537000), Somdej Kanokmedhakul (536848) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biochemistry, Medicine, Pharmacology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Aspergillus, Aspergillus aculeatus, indole diterpenoid, aculeatupene, cytotoxicity, antibacterial |
| الوصف: |
Three new indole diterpenoids, aculeatupenes A–C ( 1 – 3 ), together with four known compounds ( 4 – 7 ), were isolated from the mycelium of Aspergillus aculeatus KKU-CT2. Their structures were established by spectroscopic evidence and absolute configurations of 1 – 3 were determined by comparison of their experimental and calculated ECD spectra. Compounds 1 , 2 , and emindole SB ( 4 ) showed weak cytotoxicity against HelaS3, KB, HepG2, MCF-7, and A549 cancer cell lines with IC 50 values in the range of 11.12–67.81 μM. Compound 3 showed weak cytotoxicity against HelaS3 cell lines with an IC 50 value of 17.48 μM but non-cytotoxicity against Vero cell line. In addition, compound 1 exhibited weak antibacterial activity against Bacillus cereus. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Three_new_indole_diterpenoids_from_i_Aspergillus_aculeatus_i_KKU-CT2/14742700 |
| DOI: |
10.6084/m9.figshare.14742700.v1 |
| الاتاحة: |
https://doi.org/10.6084/m9.figshare.14742700.v1 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.1F9CEE23 |
| قاعدة البيانات: |
BASE |