التفاصيل البيبلوغرافية
| العنوان: |
Structurally Unique Salts of Cyamemazine and Their Pharmaceutical Implications |
| المؤلفون: |
Sreela Ramesh (14294283), Eliška Skořepová (1875496), Václav Eigner (1590241), Vaisakh Chelod Paingad (14294286), Vít Zvoníček (4025396), Petr Kužel (1658959), Miroslav Šoóš (4025402) |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
Biochemistry, Pharmacology, Biotechnology, Cancer, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, would help potentially, suggesting great potential, kryptoracemic behavior exhibited, already known maleate, structurally unique salts, prepared salts confirmed, maleate salts adds, dissolution rate measurement, eight acids investigated, study since one, specific solid forms, report novel salts, dissolution properties, fumaric acids, four acids, dicarboxylic acids, thermal stabilities, tartrate salts, structural features, state landscape, rare phenomenon, pharmaceutical implications |
| الوصف: |
The aim of this study was to prepare new crystalline salts of cyamemazine, an antipsychotic drug, with dicarboxylic acids, and compare their thermal stabilities, dissolution properties, and structural features. Among the eight acids investigated, we report novel salts with four acids, namely, L-malic, malonic, succinic, and fumaric acids. The study was extended to include the already known maleate and marketed L-tartrate salts as well. To the best of our knowledge, this is the first-ever study of the solid-state landscape of cyamemazine and report of its crystal structure. A rare phenomenon of kryptoracemic behavior exhibited by the L-tartrate, L-malate, and maleate salts adds an interesting perspective to this study since one of these salts is currently marketed. A powder second harmonic generation setup was developed as a tool to identify the kryptoracemates of this drug, and how this would help potentially in the production of specific solid forms of drugs is discussed. The dissolution rate measurement of the prepared salts confirmed that the succinate, L-malate, and malonate salts dissolve better and all of the new salts display improved thermal stability than the free base of the API, suggesting great potential for some of the candidates to be used for marketing purposes. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Structurally_Unique_Salts_of_Cyamemazine_and_Their_Pharmaceutical_Implications/21770589 |
| DOI: |
10.1021/acs.cgd.2c00847.s001 |
| الاتاحة: |
https://doi.org/10.1021/acs.cgd.2c00847.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.1F98355E |
| قاعدة البيانات: |
BASE |