Academic Journal
Evaluating the Efficiency of Chitosan‐Graphene Oxide Hybrid Hydrogels as Drug Delivery Systems
| العنوان: | Evaluating the Efficiency of Chitosan‐Graphene Oxide Hybrid Hydrogels as Drug Delivery Systems |
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| المؤلفون: | Di Luca, Mariagrazia, Poursani, Ensieh, Curcio, Manuela, Cirillo, Giuseppe, Salerno, Antonietta, Bolognini, Sara, De Filpo, Giovanni, Filippi, Sara, Vittorio, Orazio, Iemma, Francesca, Nicoletta, Fiore Pasquale |
| المصدر: | Macromolecular Materials and Engineering ; volume 308, issue 11 ; ISSN 1438-7492 1439-2054 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2023 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | With the objective of creating an electro‐responsive and antimicrobial device suitable as delivery system for Rose Bengal (RB) to the skin, a hybrid hydrogel combining Chitosan (CS) and Graphene Oxide (GO) are designed, serving as functional polymer support and active filling element, respectively. The hybrid system, synthesized using tripolyphosphate as a crosslinker via ionic gelation, shows a uniform and homogeneous surface, as verified by SEM investigations, high biocompatibility when tested on human fibroblast lung cells MRC‐5 cells, and biodegradability in phosphate buffered medium at physiological pH. Drug loading and release experiments, extensively analyzed using suitable mathematical modeling, shows the enhancement of the binding efficiency conferred by GO (534 and 979 mg g −1 for blank and hybrid hydrogels, respectively) and an electro‐responsive behavior (maximum BR release of 36 and 23% at 0 and 12 V, respectively). Additionally, hybrid hydrogel is found to prevent the adhesion of methicillin‐resistant Staphylococcus aureus and to kill the bacterial cells by taking advantage of the sustained release of the antimicrobial RB. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/mame.202300166 |
| الاتاحة: | http://dx.doi.org/10.1002/mame.202300166 https://onlinelibrary.wiley.com/doi/pdf/10.1002/mame.202300166 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.1F95836D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/mame.202300166 |
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