Academic Journal
Factors associated with sex differences in viral non‐suppression in the Swedish InfCareHIV cohort: An observational real‐world study
| العنوان: | Factors associated with sex differences in viral non‐suppression in the Swedish InfCareHIV cohort: An observational real‐world study |
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| المؤلفون: | Lindh, Maria, Brännström, Johanna, Reepalu, Anton, Svedhem, Veronica, Mellgren, Åsa |
| المصدر: | HIV Medicine ; volume 25, issue 5, page 540-553 ; ISSN 1464-2662 1468-1293 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2024 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Objectives Women living with HIV are underrepresented in clinical trials assessing outcomes of antiretroviral treatment (ART), justifying the need for observational studies. We investigated differences in viral non‐suppression between women and men in the Swedish InfCareHIV cohort and analysed results in relation to biological and socio‐demographic variables and patient‐reported outcome measures (PROMs). Methods The study included people living with HIV (PLWH) aged ≥18 years, who initiated ART at least 6 months prior to inclusion. Data from the InfCareHIV registry 2011–2018 were collected. Associations between variables and HIV RNA ≥50 copies/mL were investigated in uni‐ and multivariable analyses using generalized estimating equations, providing relative risks (RRs) as effect size. Results The study included 38% ( n = 2981) women. Women were more likely to have HIV RNA ≥50 copies/mL than were men [RR = 1.20, 95% confidence interval (CI): 1.10–1.31]. After adjusting for origin and route of transmission, sex at birth was no longer associated with viral non‐suppression. PROMs were available in 52.4% of PLWH, and items associated with viral non‐suppression were impaired adherence in women (RR = 2.38, 95% CI: 1.79–3.17) and men (RR 1.84, 95% CI: 1.40–2.42), and experience of side effects in women (RR = 1.49, 95% CI: 1.10–2.02). Conclusions This observational study found a 20% higher relative risk of viral non‐suppression in women than in men and the difference was associated with socio‐demographic factors. The associations between PROMs and viral non‐suppression varied between women and men. PROMs are important health outcomes that may identify PLWH in need of support to achieve viral non‐suppression. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/hiv.13607 |
| الاتاحة: | http://dx.doi.org/10.1111/hiv.13607 https://onlinelibrary.wiley.com/doi/pdf/10.1111/hiv.13607 |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.1F558BB2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/hiv.13607 |
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