Academic Journal
Dermal sensitization, safety, tolerability, and patient preference of tazarotene 0.045% lotion from five clinical trials
| العنوان: | Dermal sensitization, safety, tolerability, and patient preference of tazarotene 0.045% lotion from five clinical trials |
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| المؤلفون: | Leon H. Kircik, Lawrence Green, Eric Guenin, Waleed Khalid, Binu Alexander |
| المصدر: | Journal of Dermatological Treatment, Vol 33, Iss 4, Pp 2241-2249 (2022) |
| بيانات النشر: | Taylor & Francis Group |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | topical, retinoid, tazarotene, safety, Dermatology, RL1-803 |
| الوصف: | Background Topical retinoids are recommended for acne treatment, but their use may be limited by irritation or dermatitis. Herein is an overview of the dermal sensitization, safety, tolerability, and participant satisfaction data from phase-1, -2, and -3 studies of lower-dose tazarotene 0.045% polymeric emulsion lotion. Methods Two phase-1, single-blind, vehicle-controlled dermal safety studies were conducted in healthy participants aged ≥18 years. One phase-2 (NCT02938494) and two phase-3 studies (NCT03168334; NCT03168321) were double-blind, randomized, and vehicle-controlled over 12 weeks in participants aged ≥9 years (≥12 years, phase-2) with moderate-to-severe acne. Results A total of 2029 participants (tazarotene 0.045% lotion or vehicle) were included across the 5 studies (safety populations: n = 1982). In the phase-1 studies, tazarotene had a low potential for irritancy/contact dermatitis and did not induce sensitization. In all studies, tazarotene lotion was well tolerated and had a positive safety profile. In addition, tazarotene lotion reduced the severity of hyperpigmentation and erythema and participants preferred it more than previous acne treatments. Conclusions The results from these five studies show that the tolerability, safety, and patient satisfaction of topical tazarotene 0.045% lotion, combined with its efficacy, make it an important option for the treatment of acne. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0954-6634 1471-1753 |
| Relation: | http://dx.doi.org/10.1080/09546634.2021.1944969; https://doaj.org/toc/0954-6634; https://doaj.org/toc/1471-1753; https://doaj.org/article/bd2379cc459943999833f7f9fe5701e6 |
| DOI: | 10.1080/09546634.2021.1944969 |
| الاتاحة: | https://doi.org/10.1080/09546634.2021.1944969 https://doaj.org/article/bd2379cc459943999833f7f9fe5701e6 |
| رقم الانضمام: | edsbas.1F3AEE55 |
| قاعدة البيانات: | BASE |
| تدمد: | 09546634 14711753 |
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| DOI: | 10.1080/09546634.2021.1944969 |