Academic Journal
Gemfibrozil attenuates doxorubicin induced toxicity in renal tissues of male rats by reducing the oxidative insult and inflammation
| العنوان: | Gemfibrozil attenuates doxorubicin induced toxicity in renal tissues of male rats by reducing the oxidative insult and inflammation |
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| المؤلفون: | Hosseinzadeh, A., Goudarzi, M., Fatemi, I., Khodayar, M.J., Mehrzadi, S., Khalili, H.R., Karimi, M.A. |
| سنة النشر: | 2020 |
| المجموعة: | eprints Iran University of Medical Sciences |
| مصطلحات موضوعية: | WJ Urogenital System, QV Pharmacology |
| الوصف: | Nephrotoxicity is a significant side effect of doxorubicin (DXN) treatment. We investigated the protective effect of gemfibrozil (GEM) co-administration with DXN on DXN induced nephrotoxicity. We divided 28 male Wistar rats into four groups of seven. Group 1 received normal saline for 2 weeks. Group 2 received 15 mg/kg DXN for 2 weeks. Group 3 received DXN + GEM for 2 weeks. Group 4 received GEM for 2 weeks. On day 15 of the experiment, blood samples were collected, animals were sacrificed and kidneys were excised for biochemical and histological evaluation. We measured serum creatinine, blood urine nitrogen, renal malondialdehyde, nitric oxide, glutathione, superoxide dismutase, glutathione peroxidase, catalase, tumor necrosis factor-α and interleukin-1β. GEM administration mitigated DXN induced nephrotoxicity. GEM co-administered with DXN attenuated the inflammatory and oxidative responses associated with DXN induced nephrotoxicity. © 2020 The Biological Stain Commission. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | Hosseinzadeh, A. and Goudarzi, M. and Fatemi, I. and Khodayar, M.J. and Mehrzadi, S. and Khalili, H.R. and Karimi, M.A. (2020) Gemfibrozil attenuates doxorubicin induced toxicity in renal tissues of male rats by reducing the oxidative insult and inflammation. Biotechnic and Histochemistry, 95 (7). pp. 532-539. |
| الاتاحة: | http://eprints.iums.ac.ir/33862/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082948224&doi=10.1080%2f10520295.2020.1730967&partnerID=40&md5=3d630973546eb3b01bd5748ec8fd17a5 |
| رقم الانضمام: | edsbas.1F32682 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |