التفاصيل البيبلوغرافية
| العنوان: |
An implantable soft robotic ventilator augments inspiration in a pig model of respiratory insufficiency |
| المؤلفون: |
Hu, Lucy, Bonnemain, Jean, Saeed, Mossab Y., Singh, Manisha, Quevedo Moreno, Diego, Vasilyev, Nikolay V., Roche, Ellen T. |
| المصدر: |
Springer Science and Business Media LLC |
| بيانات النشر: |
Springer Science and Business Media LLC |
| سنة النشر: |
2024 |
| المجموعة: |
DSpace@MIT (Massachusetts Institute of Technology) |
| مصطلحات موضوعية: |
Computer Science Applications, Biomedical Engineering, Medicine (miscellaneous), Bioengineering, Biotechnology |
| الوصف: |
Severe diaphragm dysfunction can lead to respiratory failure and to the need for permanent mechanical ventilation. Yet permanent tethering to a mechanical ventilator through the mouth or via tracheostomy can hinder a patient’s speech, swallowing ability and mobility. Here we show, in a porcine model of varied respiratory insufficiency, that a contractile soft robotic actuator implanted above the diaphragm augments its motion during inspiration. Synchronized actuation of the diaphragm-assist implant with the native respiratory effort increased tidal volumes and maintained ventilation flow rates within the normal range. Robotic implants that intervene at the diaphragm rather than at the upper airway and that augment physiological metrics of ventilation may restore respiratory performance without sacrificing quality of life. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Nature Biomedical Engineering; https://hdl.handle.net/1721.1/154124; Hu, L., Bonnemain, J., Saeed, M.Y. et al. An implantable soft robotic ventilator augments inspiration in a pig model of respiratory insufficiency. Nat. Biomed. Eng 7, 110–123 (2023). |
| الاتاحة: |
https://hdl.handle.net/1721.1/154124 |
| Rights: |
Creative Commons Attribution ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.1F14904 |
| قاعدة البيانات: |
BASE |