Academic Journal
Complete versus incomplete revascularization in patients with a non-ST-elevation myocardial infarction: Analysis from the e-ULTIMASTER registry.
| العنوان: | Complete versus incomplete revascularization in patients with a non-ST-elevation myocardial infarction: Analysis from the e-ULTIMASTER registry. |
|---|---|
| المؤلفون: | Jiménez DÃaz, Victor A, Routledge, Helen, Malik, Fazila-Tun-Nesa, Hildick-Smith, David, Guédès, Antoine, Baello, Pascual, Kuramitsu, Shoichi, Das, Rajiv, Dewilde, Willem, Portales, Javier Fernandez, Angioi, Michael, Smits, Pieter C, Romo, Andrés Iñiguez |
| المساهمون: | UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de cardiologie |
| المصدر: | Cardiovascular revascularization medicine : including molecular interventions, (2024) |
| سنة النشر: | 2024 |
| المجموعة: | DIAL@UCL (Université catholique de Louvain) |
| مصطلحات موضوعية: | Clinical study, Coronary stent, Myocardial infarction, Non-ST-elevation myocardial infarction, Percutaneous coronary intervention, Ultimaster |
| الوصف: | Incomplete revascularization (ICR) has been associated with a worse prognosis after a percutaneous coronary intervention (PCI). In NSTEMI patients with multivessel disease (MVD) however, the benefit of a complete revascularization (CR) remains unclear. Patients presenting with an NSTEMI and MVD were selected from the global e-ULTIMASTER registry and grouped according to completeness of revascularization at index hospitalization discharge. The primary endpoint was the patient oriented composite endpoint (POCE) defined as all death, any myocardial infarction, and any revascularization at 1 year. Target lesion failure (TLF) was defined as the composite of cardiac death, target vessel related myocardial infarction and clinically driven target lesion revascularization. Inverse propensity score weighting (IPSW) was performed to harmonize the patient's baseline characteristics between the groups. CR was achieved in 1800 patients (47.0 %) and ICR in 2032 patients (53.0 %). The incidence of POCE at 1 year was lower in the CR group compared to the ICR group: 7.0 % vs. 12.9 %, p < 0.0001. Similarly for TLF at 1 year: 3.6 % vs. 5.5 %, p < 0.01. After IPSW, the incidence of POCE was 7.7 % vs. 12.0 %, p < 0.0001, due to a lower all-cause mortality: 2.7 % vs. 4.2 %, p = 0.02 and less revascularizations: 4.9 % vs. 7.9 %, p < 0.001. The incidence of TLF was no longer statistically significant: CR 3.9 % vs. IR 5.0 %, p = 0.10. Patients with a NSTEMI and multi vessel disease undergoing a percutaneous coronary revascularization with a complete revascularization during index hospitalization have better 1-year clinical outcomes. Randomized studies are warranted to confirm these results. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1878-0938 |
| Relation: | boreal:290622; http://hdl.handle.net/2078.1/290622; info:pmid/39079857; urn:EISSN:1878-0938 |
| DOI: | 10.1016/j.carrev.2024.07.011 |
| الاتاحة: | http://hdl.handle.net/2078.1/290622 https://doi.org/10.1016/j.carrev.2024.07.011 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1ED5F96E |
| قاعدة البيانات: | BASE |
| تدمد: | 18780938 |
|---|---|
| DOI: | 10.1016/j.carrev.2024.07.011 |