Academic Journal
Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study
| العنوان: | Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study |
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| المؤلفون: | Santos-Galduróz, Ruth Ferreira, Galduróz, José Carlos Fernandes UNIFESP, Facco, R.L., Hachul, Helena UNIFESP, Tufik, Sergio UNIFESP |
| المساهمون: | Universidade Estadual Paulista (UNESP), Universidade Federal do ABC Centro de Matemática, Computação e Cognição, Universidade Federal de São Paulo (UNIFESP), Independent researcher in private practice Departamento de Psicobiologia |
| بيانات النشر: | Associação Brasileira de Divulgação Científica |
| سنة النشر: | 2010 |
| المجموعة: | Universidade Federal de São Paulo (UNIFESP): Repositório Institucional |
| مصطلحات موضوعية: | Isoflavone, Cognitive disorders, Aging, Information integration, Memory, Menopause |
| الوصف: | Hormone decline is common to all women during aging and, associated with other factors, leads to cognitive impairment. Its replacement enhances cognitive performance, but not all women present a clinical and family or personal history that justifies its use, mainly women with a history of cancer. The aim of this study was to determine whether a daily oral dose of 80 mg of isoflavone extract for 4 months can produce benefits in women with low hormone levels, contributing to improvement in cognitive aspects. The sample comprised 50- to 65-year-old women whose menstruation had ceased at least 1 year before and who had not undergone hormone replacement. The volunteers were allocated to two groups of 19 individuals each, i.e., isoflavone and placebo. There was a weak correlation between menopause duration and low performance in the capacity to manipulate information (central executive). We observed an increase in the capacity to integrate information in the group treated with isoflavone, but no improvement in the capacity to form new memories. We did not observe differences between groups in terms of signs and symptoms suggestive of depression according to the Geriatric Depression Scale. Our results point to a possible beneficial effect of isoflavone on some abilities of the central executive. These effects could also contribute to minimizing the impact of memory impairment. Further research based on controlled clinical trials is necessary to reach consistent conclusions. ; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) ; Associação Fundo de Incentivo à Pesquisa (AFIP) ; Universidade Estadual Paulista Departamento de Biociências ; Universidade Federal do ABC Centro de Matemática, Computação e Cognição ; Universidade Federal de São Paulo (UNIFESP) Departamento de Psicobiologia ; Independent researcher in private practice Departamento de Psicobiologia ; UNIFESP, Depto. de Psicobiologia ; SciELO |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 1123-1126; application/pdf |
| اللغة: | English |
| تدمد: | 0100-879X |
| Relation: | Brazilian Journal of Medical and Biological Research; http://dx.doi.org/10.1590/S0100-879X2010007500104; Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 43, n. 11, p. 1123-1126, 2010.; http://repositorio.unifesp.br/handle/11600/6006; S0100-879X2010001100016.pdf; S0100-879X2010001100016; WOS:000284591800016 |
| DOI: | 10.1590/S0100-879X2010007500104 |
| الاتاحة: | http://repositorio.unifesp.br/handle/11600/6006 https://doi.org/10.1590/S0100-879X2010007500104 |
| Rights: | Acesso aberto |
| رقم الانضمام: | edsbas.1EC40975 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 0100879X |
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| DOI: | 10.1590/S0100-879X2010007500104 |