Academic Journal
The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine
| العنوان: | The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine |
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| المؤلفون: | Schwartz, J.C., Hemmink, J.D., Graham, S.P., Tchilian, E., Charleston, B., Hammer, S.E., Ho, C.S., Hammond, John A. |
| المصدر: | HLA |
| بيانات النشر: | Wiley |
| سنة النشر: | 2019 |
| المجموعة: | CGIAR CGSpace (Consultative Group on International Agricultural Research) |
| مصطلحات موضوعية: | animal breeding, genetics, swine |
| الوصف: | The Babraham pig is a highly inbred breed first developed in the United Kingdom approximately 50 years ago. Previous reports indicate a very high degree of homozygosity across the genome, including the major histocompatibility complex (MHC) region, but confirmation of homozygosity at the specific MHC loci was lacking. Using both direct sequencing and PCR‐based sequence‐specific typing, we confirm that Babraham pigs are essentially homozygous at their MHC loci and formalise their MHC haplotype as Hp‐55.6. This enhances the utility of the Babraham pig as a useful biomedical model for studies in which controlling for genetic variation is important. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | p. 40-43 |
| اللغة: | English |
| تدمد: | 2059-2310 |
| Relation: | Schwartz, J.C., Hemmink, J.D., Graham, S.P., Tchilian, E., Charleston, B., Hammer, S.E., Ho, C.S. and Hammond, J.A. 2018. The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine. HLA 92:40–43.; https://hdl.handle.net/10568/99010; https://doi.org/10.1111/tan.13281 |
| DOI: | 10.1111/tan.13281 |
| الاتاحة: | https://hdl.handle.net/10568/99010 https://doi.org/10.1111/tan.13281 |
| Rights: | CC-BY-4.0 ; Open Access |
| رقم الانضمام: | edsbas.1EAB3304 |
| قاعدة البيانات: | BASE |
| تدمد: | 20592310 |
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| DOI: | 10.1111/tan.13281 |