Academic Journal
Plasma triglycerides and LDL cholesterol are related in a parabolic fashion in the general population and patients with Type 2 diabetes mellitus: long-term follow-up results from the Hoorn study
| العنوان: | Plasma triglycerides and LDL cholesterol are related in a parabolic fashion in the general population and patients with Type 2 diabetes mellitus: long-term follow-up results from the Hoorn study |
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| المؤلفون: | Brouwers, M.C., Dekker, J.M., van Greevenbroek, M.M., van der Kallen, C.J., Heine, R.J., de Bruin, T.W., Stehouwer, C.D. |
| المصدر: | Brouwers , M C , Dekker , J M , van Greevenbroek , M M , van der Kallen , C J , Heine , R J , de Bruin , T W & Stehouwer , C D 2008 , ' Plasma triglycerides and LDL cholesterol are related in a parabolic fashion in the general population and patients with Type 2 diabetes mellitus: long-term follow-up results from the Hoorn study ' , Diabetic Medicine , vol. 25 , no. 9 , pp. 1121-4 . https://doi.org/10.1111/j.1464-5491.2008.02524.x |
| سنة النشر: | 2008 |
| المجموعة: | Maastricht University Research Publications |
| الوصف: | AIMS: Low-density lipoprotein cholesterol (LDL-C) levels are often fairly normal in Type 2 diabetes mellitus (DM). We anticipated that a parabolic relation between plasma triglycerides and LDL-C, as previously demonstrated in familial combined hyperlipidaemia (FCHL), might account for this phenomenon. METHODS: Our hypothesis was tested in 1343 subjects derived from the general population who were studied on two occasions 6 years apart (the Hoorn study). Three groups were constructed depending on plasma triglycerides: group A (individuals with both measurements below 1.5 mmol/l), group B (one measurement below and one above 1.5 mmol/l) and group C (both measurements above 1.5 mmol/l). Diabetes status was ascertained by an oral glucose tolerance test. RESULTS: In a mixed linear model, a significant, positive relation between triglycerides and LDL-C was observed for males in group A (beta(a) = 0.5, P < 0.001) and group B (beta(b) = 0.2, P < 0.001), whereas a significant negative relation was found for males in group C (beta(c) = -0.2, P = 0.003). The regression slopes did not differ between diabetic and non-diabetic subjects. Similar results were obtained for women, with the exception that the relation was not significantly negative in group C (beta(c) = -0.1, P = 0.4). CONCLUSION: Plasma triglycerides and LDL-C are related in a parabolic fashion, not only in FCHL, but also in the general population and Type 2 DM. These findings aid our interpretation of typical dyslipidaemia and the effects of treatment that are frequently observed in hypertriglyceridaemic states. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/j.1464-5491.2008.02524.x |
| الاتاحة: | https://cris.maastrichtuniversity.nl/en/publications/55133ab7-51c4-4d06-a247-452defcd2eb9 https://doi.org/10.1111/j.1464-5491.2008.02524.x |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.1EA20BD0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1464-5491.2008.02524.x |
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