Academic Journal
TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet.
| العنوان: | TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet. |
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| المؤلفون: | Grau, K., Cauchi, S., Holst, C., Astrup, A., Martinez, J.A., Saris, W.H., Blaak, E.E., Oppert, J.M., Arner, P., Rossner, S., Macdonald, I.A., Klimcakova, E., Langin, D., Pedersen, O., Froguel, P., Sorensen, T.I. |
| المصدر: | Grau , K , Cauchi , S , Holst , C , Astrup , A , Martinez , J A , Saris , W H , Blaak , E E , Oppert , J M , Arner , P , Rossner , S , Macdonald , I A , Klimcakova , E , Langin , D , Pedersen , O , Froguel , P & Sorensen , T I 2010 , ' TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet. ' , American Journal of Clinical Nutrition , vol. 91 , no. 2 , .... |
| سنة النشر: | 2010 |
| المجموعة: | Maastricht University Research Publications |
| مصطلحات موضوعية: | HOMEOSTASIS MODEL ASSESSMENT, TYPE-2 DIABETIC-PATIENTS, BETA-CELL FUNCTION, INSULIN-RESISTANCE, GENE POLYMORPHISMS, ENERGY-INTAKE, HIGH-FAT, GLUCOSE, RISK, SUSCEPTIBILITY |
| الوصف: | BACKGROUND: Transcription factor 7-like 2 (TCF7L2) rs7903146 associates with type 2 diabetes and may operate via impaired glucagon-like peptide 1 secretion, which is stimulated more by fat than by carbohydrate ingestion. OBJECTIVE: The objective was to examine the interaction between TCF7L2 rs7903146 and dietary fat and carbohydrate [high-fat, low-carbohydrate: 40-45% of energy as fat (HF); compared with low-fat, high-carbohydrate: 20-25% of energy as fat (LF)] in obese individuals' responses to a 10-wk hypoenergetic diet (-600 kcal/d). DESIGN: European, obese participants (n = 771) were randomly assigned to receive an HF or an LF diet. Body weight, fat mass (FM), fat-free mass (FFM), waist circumference (WC), resting energy expenditure (REE), fasting fat oxidation in percentage of REE (FatOx), homeostasis model assessed insulin release (HOMA-beta), and HOMA-insulin resistance (HOMA-IR) were determined at baseline and after the intervention; 739 individuals were genotyped for rs7903146. RESULTS: Average weight loss was 6.9 kg with the LF and 6.6 kg with the HF (difference between diets, NS) diet. Among individuals who were homozygous for the T-risk allele, those in the HF diet group experienced smaller weight losses (Deltaweight) (2.6 kg; P = 0.009; n = 622), smaller DeltaFFM (1.6 kg; P = 0.027; n = 609), smaller DeltaWC (3.3 cm; P = 0.010; n = 608), and a smaller DeltaHOMA-IR (1.3 units; P = 0.004; n = 615) than did the LF diet group. For C allele carriers, there were no differences between the HF and LF diet groups. For the HF diet group, each additional T allele was associated with a reduced loss of FM (0.67 kg; P = 0.019; n = 609). TCF7L2 rs7903146 was not associated with DeltaREE, DeltaFatOx, DeltaHOMA-beta, or dropout. CONCLUSION: Our results suggest that obese individuals who are homozygous for the TCF7L2 rs7903146 T-risk allele are more sensitive to LF than to HF weight-loss diets. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://cris.maastrichtuniversity.nl/en/publications/e4641f42-7187-4c14-9eec-78b6af8e178c |
| DOI: | 10.3945/ajcn.2009.27947 |
| الاتاحة: | https://cris.maastrichtuniversity.nl/en/publications/e4641f42-7187-4c14-9eec-78b6af8e178c https://doi.org/10.3945/ajcn.2009.27947 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1E8EA018 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3945/ajcn.2009.27947 |
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