Academic Journal
Immune parameters to p67C antigen adjuvanted with ISA206VG correlate with protection against East Coast fever
| العنوان: | Immune parameters to p67C antigen adjuvanted with ISA206VG correlate with protection against East Coast fever |
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| المؤلفون: | Lacasta, Anna, Mwalimu, Stephen, Kibwana, Elisabeth, Saya, R., Awino, Elias, Njoroge, Thomas, Poole, Elizabeth J., Ndiwa, Nicholas N., Pelle, Roger, Nene, Vishvanath, Steinaa, Lucilla |
| المصدر: | Vaccine |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2018 |
| المجموعة: | CGIAR CGSpace (Consultative Group on International Agricultural Research) |
| مصطلحات موضوعية: | theileria, cattle, animal diseases, vaccines, disease control, east coast fever |
| الوصف: | East Coast fever (ECF) is a lymphoproliferative disease caused by the tick-transmitted protozoan parasite Theileria parva. ECF is one of the most serious cattle tick-borne diseases in Sub-Saharan Africa. We have previously demonstrated that three doses of the C-terminal part of the sporozoite protein p67 (p67C) adjuvanted with ISA206VG confers partial protection against ECF at a herd level. We have tested the efficacy of two doses of this experimental vaccine, as reducing the vaccination regimen would facilitate its deployment in the field. We reconfirm that three antigen doses gave a significant level of protection to severe disease (46%, ECF score < 6) when compared with the control group, while two doses did not (23%). Animals receiving three doses of p67C developed higher antibody titers and CD4+ T-cell proliferation indices, than those which received two doses. A new panel of immune parameters were tested in order to identify factors correlating with protection: CD4+ proliferation index, total IgG, IgG1, IgG2 and IgM half maximal titers and neutralization capacity of the sera with and without complement. We show that some of the cellular and humoral immune responses provide preliminary correlates of protection. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | p. 1389-1397 |
| اللغة: | English |
| تدمد: | 0264-410X |
| Relation: | Lacasta, A., Mwalimu, S., Kibwana, E., Saya, R., Awino, E., Njoroge, T., Poole, J., Ndiwa, N., Pelle, R., Nene, V. and Steinaa, L. 2018. Immune parameters to p67C antigen adjuvanted with ISA206VG correlate with protection against East Coast fever. Vaccine 36(11):1389–1397.; https://hdl.handle.net/10568/91022; https://doi.org/10.1016/j.vaccine.2018.01.087 |
| DOI: | 10.1016/j.vaccine.2018.01.087 |
| الاتاحة: | https://hdl.handle.net/10568/91022 https://doi.org/10.1016/j.vaccine.2018.01.087 |
| Rights: | CC-BY-4.0 ; Open Access |
| رقم الانضمام: | edsbas.1E3C2904 |
| قاعدة البيانات: | BASE |
| تدمد: | 0264410X |
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| DOI: | 10.1016/j.vaccine.2018.01.087 |