Academic Journal
Microscopic fractures shown inside tablets after impact
| العنوان: | Microscopic fractures shown inside tablets after impact |
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| المؤلفون: | Carlson, Craig, Stuart, Postema, Michiel, Anderton, Nicole, Hannula, Markus, Sorjonen, Joona, Xinyue, Hu, Otake, Naoyuki, Kudo, Nobuki, Hyttinen, Jari, Ketolainen, Jarkko |
| المساهمون: | BioMediTech Institute Tampere, University of Tampere Finland, University of the Witwatersrand Johannesburg (WITS), University of Eastern Finland, Hokkaido University Sapporo, Japan, JSPS KAKENHI, Grant No. JP17H00864 and JP20H04542, National Research Foundation of South Africa, Grant No. 127102, Academy of Finland, Grant No. 340026 |
| المصدر: | ISSN: 0021-4922 ; Japanese Journal of Applied Physics ; https://hal.science/hal-04411113 ; Japanese Journal of Applied Physics, In press, 63, ⟨10.35848/1347-4065/ad21be⟩. |
| بيانات النشر: | HAL CCSD Japan Society of Applied Physics |
| سنة النشر: | 2024 |
| المجموعة: | Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
| مصطلحات موضوعية: | [PHYS.PHYS.PHYS-FLU-DYN]Physics [physics]/Physics [physics]/Fluid Dynamics [physics.flu-dyn] |
| الوصف: | International audience ; In prior work, rough handling of oral tablets had been observed to drastically speed up their disintegration in water. The purpose of this study was to confirm or refute that the formation of internal microscopic fractures during rough handling is the underlying mechanism. Impacted and control tablets were subjected to micro-computed tomography and to brightness-mode ultrasound. The former revealed fracturing with a maximum crack width of 14 $\mu$m. The latter revealed strong acoustic response from the internal structure of the impacted tablets. These results confirm the hypothesis. Disintegration speed is used as a quality control mechanism after tablet manufacturing and transportation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | hal-04411113; https://hal.science/hal-04411113 |
| DOI: | 10.35848/1347-4065/ad21be |
| الاتاحة: | https://hal.science/hal-04411113 https://doi.org/10.35848/1347-4065/ad21be |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/ |
| رقم الانضمام: | edsbas.1E3B74BA |
| قاعدة البيانات: | BASE |
| DOI: | 10.35848/1347-4065/ad21be |
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