Academic Journal
Common Susceptibility Loci for Male Breast Cancer.
| العنوان: | Common Susceptibility Loci for Male Breast Cancer. |
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| المؤلفون: | Maguire, S, Perraki, E, Tomczyk, K, Jones, ME, Fletcher, O, Pugh, M, Winter, T, Thompson, K, Cooke, R, kConFab Consortium, Trainer, A, James, P, Bojesen, S, Flyger, H, Nevanlinna, H, Mattson, J, Friedman, E, Laitman, Y, Palli, D, Masala, G, Zanna, I, Ottini, L, Silvestri, V, Hollestelle, A, Hooning, MJ, Novaković, S, Krajc, M, Gago-Dominguez, M, Castelao, JE, Olsson, H, Hedenfalk, I, Saloustros, E, Georgoulias, V, Easton, DF, Pharoah, P, Dunning, AM, Bishop, DT, Neuhausen, SL, Steele, L, Ashworth, A, Garcia Closas, M, Houlston, R, Swerdlow, A, Orr, N |
| المساهمون: | Perraki, Eleni, Jones, Michael, Fletcher, Olivia, Houlston, Richard, Swerdlow, Anthony |
| بيانات النشر: | OXFORD UNIV PRESS INC |
| سنة النشر: | 2020 |
| المجموعة: | The Institute of Cancer Research (ICR): Publications Repository |
| مصطلحات موضوعية: | kConFab Consortium |
| الوصف: | BACKGROUND: The etiology of male breast cancer (MBC) is poorly understood. In particular, the extent to which the genetic basis of MBC differs from female breast cancer (FBC) is unknown. A previous genome-wide association study of MBC identified 2 predisposition loci for the disease, both of which were also associated with risk of FBC. METHODS: We performed genome-wide single nucleotide polymorphism genotyping of European ancestry MBC case subjects and controls in 3 stages. Associations between directly genotyped and imputed single nucleotide polymorphisms with MBC were assessed using fixed-effects meta-analysis of 1380 cases and 3620 controls. Replication genotyping of 810 cases and 1026 controls was used to validate variants with P values less than 1 × 10-06. Genetic correlation with FBC was evaluated using linkage disequilibrium score regression, by comprehensively examining the associations of published FBC risk loci with risk of MBC and by assessing associations between a FBC polygenic risk score and MBC. All statistical tests were 2-sided. RESULTS: The genome-wide association study identified 3 novel MBC susceptibility loci that attained genome-wide statistical significance (P < 5 × 10-08). Genetic correlation analysis revealed a strong shared genetic basis with estrogen receptor-positive FBC. Men in the top quintile of genetic risk had a fourfold increased risk of breast cancer relative to those in the bottom quintile (odds ratio = 3.86, 95% confidence interval = 3.07 to 4.87, P = 2.08 × 10-30). CONCLUSIONS: These findings advance our understanding of the genetic basis of MBC, providing support for an overlapping genetic etiology with FBC and identifying a fourfold high-risk group of susceptible men. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | Print-Electronic; application/pdf |
| اللغة: | English |
| تدمد: | 0027-8874 1460-2105 |
| Relation: | Journal of the National Cancer Institute, 2020; https://repository.icr.ac.uk/handle/internal/4007 |
| DOI: | 10.1093/jnci/djaa101 |
| الاتاحة: | https://repository.icr.ac.uk/handle/internal/4007 https://doi.org/10.1093/jnci/djaa101 |
| Rights: | https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.1DFE3CF9 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00278874 14602105 |
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| DOI: | 10.1093/jnci/djaa101 |