Academic Journal
Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair.
| العنوان: | Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair. |
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| المؤلفون: | Munz, B., Smola, H., Engelhardt, F., Bleuel, K., Brauchle, M., Lein, I., Evans, L. W., Huylebroeck, D., BALLING, Rudi, Werner, S. |
| المصدر: | EMBO Journal, 18 (19), 5205-15 (1999) |
| بيانات النشر: | Wiley-Blackwell |
| سنة النشر: | 1999 |
| المجموعة: | University of Luxembourg: ORBilu - Open Repository and Bibliography |
| مصطلحات موضوعية: | Activins, Animals, Cell Differentiation, Cell Division, Cloning, Molecular, Epidermis/metabolism/pathology, Fibronectins/genetics/metabolism, Inhibins/metabolism, Keratinocytes/cytology/metabolism, Membrane Glycoproteins/metabolism, Mice, Transgenic, Morphogenesis, RNA, Messenger/genetics/metabolism, Skin/metabolism/pathology, Tenascin/metabolism, Wound Healing, Life sciences, Genetics & genetic processes, Sciences du vivant, Génétique & processus génétiques |
| الوصف: | peer reviewed ; Recently we demonstrated a strong induction of activin expression after skin injury, suggesting a function of this transforming growth factor-beta family member in wound repair. To test this possibility, we generated transgenic mice that overexpress the activin betaA chain in the epidermis under the control of a keratin 14 promoter. The transgenic mice were significantly smaller than control littermates, and they had smaller ears and shorter tails. In their skin, the fatty tissue was replaced by connective tissue and a severe thickening of the epidermis was found. The spinous cell layer was significantly increased, and the epidermal architecture was highly disorganized. These histological abnormalities seem to result from increased proliferation of the basal keratinocytes and abnormalities in the program of keratinocyte differentiation. After skin injury, a significant enhancement of granulation tissue formation was detected in the activin-overexpressing mice, possibly as a result of premature induction of fibronectin and tenascin-C expression. These data reveal novel activities of activin in the regulation of keratinocyte proliferation and differentiation as well as in dermal fibrosis and cutaneous wound repair. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0261-4189 1460-2075 |
| Relation: | urn:issn:0261-4189; urn:issn:1460-2075; https://orbilu.uni.lu/handle/10993/1324; info:hdl:10993/1324; info:pmid: 10508154; wos:000083140800006 |
| DOI: | 10.1093/emboj/18.19.5205 |
| الاتاحة: | https://orbilu.uni.lu/handle/10993/1324 https://doi.org/10.1093/emboj/18.19.5205 |
| رقم الانضمام: | edsbas.1DAD6080 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 02614189 14602075 |
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| DOI: | 10.1093/emboj/18.19.5205 |