التفاصيل البيبلوغرافية
| العنوان: |
Quantifying Proximity, Confinement, and Interventions in Disease Outbreaks: A Decision Support Framework for Air-Transported Pathogens |
| المؤلفون: |
Tami C. Bond (537562), Angela Bosco-Lauth (589963), Delphine K. Farmer (773814), Paul W. Francisco (6565466), Jeffrey R. Pierce (2366257), Kristen M. Fedak (6812591), Jay M. Ham (7817792), Shantanu H. Jathar (1869691), Sue VandeWoude (43771) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Medicine, Biotechnology, Ecology, Cancer, Science Policy, Infectious Diseases, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, confinement effect, ERBV 1, mitigation measures, 2 m, ERBV 10, COVID -19 pandemic, Air-Transported Pathogens, mitigation decisions, ERBV 100, Quantifying Proximity, office situations, particle diameters, 1 μ m particles, 100 μ m, size-dependent ERBV, Effective ReBreathed Volume, 100 μ m particles, Particle size, Pathogen transport, transmission modes, Disease Outbreaks |
| الوصف: |
The inability to communicate how infectious diseases are transmitted in human environments has triggered avoidance of interactions during the COVID-19 pandemic. We define a metric, Effective ReBreathed Volume (ERBV), that encapsulates how infectious pathogens, including SARS-CoV-2, transport in air. ERBV separates environmental transport from other factors in the chain of infection, allowing quantitative comparisons among situations. Particle size affects transport, removal onto surfaces, and elimination by mitigation measures, so ERBV is presented for a range of exhaled particle diameters: 1, 10, and 100 μm. Pathogen transport depends on both proximity and confinement. If interpersonal distancing of 2 m is maintained, then confinement, not proximity, dominates rebreathing after 10–15 min in enclosed spaces for all but 100 μm particles. We analyze strategies to reduce this confinement effect. Ventilation and filtration reduce person-to-person transport of 1 μm particles (ERBV 1 ) by 13–85% in residential and office situations. Deposition to surfaces competes with intentional removal for 10 and 100 μm particles, so the same interventions reduce ERBV 10 by only 3–50%, and ERBV 100 is unaffected. Prior knowledge of size-dependent ERBV would help identify transmission modes and effective interventions. This framework supports mitigation decisions in emerging situations, even before other infectious parameters are known. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Quantifying_Proximity_Confinement_and_Interventions_in_Disease_Outbreaks_A_Decision_Support_Framework_for_Air-Transported_Pathogens/14061305 |
| DOI: |
10.1021/acs.est.0c07721.s001 |
| الاتاحة: |
https://doi.org/10.1021/acs.est.0c07721.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.1D8F7E46 |
| قاعدة البيانات: |
BASE |