Academic Journal
Yeast stress granules at a glance
| العنوان: | Yeast stress granules at a glance |
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| المؤلفون: | Grousl, Tomas, Vojtova, Jana, Hasek, Jiri, Vomastek, Tomas |
| المساهمون: | Grantová Agentura České Republiky |
| المصدر: | Yeast ; volume 39, issue 4, page 247-261 ; ISSN 0749-503X 1097-0061 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2021 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | The formation of stress granules (SGs), membrane‐less organelles that are composed of mainly messenger ribonucleoprotein assemblies, is the result of a conserved evolutionary strategy to cellular stress. During their formation, which is triggered by robust environmental stress, SGs sequester translationally inactive mRNA molecules, which are either forwarded for further processing elsewhere or stored during a period of stress within SGs. Removal of mRNA molecules from active translation and their sequestration in SGs allows preferential translation of stress response transcripts. By affecting the specificity of mRNA translation, mRNA localization and stability, SGs are involved in the overall cellular reprogramming during periods of environmental stress and viral infection. Over the past two decades, we have learned which processes drive SGs assembly, how their composition varies under stress, and how they co‐exist with other subcellular organelles. Yeast as a model has been instrumental in our understanding of SG biology. Despite the specific differences between the SGs of yeast and mammals, yeast have been shown to be a valuable tool to the study of SGs in translation‐related stress response. This review summarizes the data surrounding SGs that are formed under different stress conditions in Saccharomyces cerevisiae and other yeast species. It offers a comprehensive and up‐to‐date view on these still somewhat mysterious entities. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/yea.3681 |
| الاتاحة: | http://dx.doi.org/10.1002/yea.3681 https://onlinelibrary.wiley.com/doi/pdf/10.1002/yea.3681 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/yea.3681 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.1D5AFAF4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/yea.3681 |
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