Academic Journal
Hydrogen borrowing-based methods for the construction of quaternary stereocentres
| العنوان: | Hydrogen borrowing-based methods for the construction of quaternary stereocentres |
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| المؤلفون: | Crompton, J, Jenkins, T, Rowe, S, Donohoe, T |
| بيانات النشر: | Wiley |
| سنة النشر: | 2025 |
| المجموعة: | Oxford University Research Archive (ORA) |
| الوصف: | Compounds containing quaternary stereocentres are a valuable motif in biologically active compounds. Herein we present our strategy to utilise the hydrogen borrowing manifold to access α-quaternary ketones via a tandem acceptorless dehydrogenation-cyclisation cascade. This new application of the methodology results in the formation of five- and six-membered carbocycles with a high degree of diastereoselectivity. Interestingly, benzylic alcohol substrates behaved anomalously and eliminated sulfinate in situ to give a set of rearranged α-quaternary ketone products. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://doi.org/10.1002/anie.202423179 |
| DOI: | 10.1002/anie.202423179 |
| الاتاحة: | https://doi.org/10.1002/anie.202423179 https://ora.ox.ac.uk/objects/uuid:e462406b-05ed-4622-a1a9-bc805849e900 |
| Rights: | info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| رقم الانضمام: | edsbas.1D3A0E78 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/anie.202423179 |
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