Academic Journal
Does Metformin Treatment during Pregnancy Modify the Future Metabolic Profile in Women with PCOS?
| العنوان: | Does Metformin Treatment during Pregnancy Modify the Future Metabolic Profile in Women with PCOS? |
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| المؤلفون: | Underdal, Maria Othelie, Stridsklev, Solhild, Oppen, Ingrid Hennum, Høgetveit, Kristin, Andersen, Marianne Skovsager, Vanky, Eszter |
| المصدر: | Underdal , M O , Stridsklev , S , Oppen , I H , Høgetveit , K , Andersen , M S & Vanky , E 2018 , ' Does Metformin Treatment during Pregnancy Modify the Future Metabolic Profile in Women with PCOS? ' , The Journal of Clinical Endocrinology & Metabolism , vol. 103 , no. 6 , pp. 2408–2413 . https://doi.org/10.1210/jc.2018-00485 |
| سنة النشر: | 2018 |
| المجموعة: | University of Southern Denmark: Research Output / Syddansk Universitet |
| مصطلحات موضوعية: | Adult, Blood Glucose, Blood Pressure/drug effects, Body Mass Index, Female, Follow-Up Studies, Humans, Hypoglycemic Agents/administration & dosage, Insulin Resistance/physiology, Insulin/blood, Lipids/blood, Metformin/administration & dosage, Polycystic Ovary Syndrome/blood, Pregnancy, Pregnancy Complications/blood, Pregnancy Trimester, First, Waist Circumference/drug effects |
| الوصف: | Context Worldwide, metformin is prescribed to improve pregnancy outcome in polycystic ovary syndrome (PCOS). Metformin may also benefit future health by modulating increased metabolic stress during pregnancy. Objective To investigate whether metformin during pregnancy modified future metabolic health in women with PCOS. Design Follow-up study of a randomized controlled trial that compared metformin with placebo in women with PCOS. Mean follow-up period was 7.7 years (range, 5 to 11 years). Setting Three university hospitals, seven local hospitals, and one gynecological specialist practice. Participants Women with PCOS according to Rotterdam criteria; all former participants in the Metformin in Pregnant PCOS Women Study. Intervention Metformin 2000 mg daily or placebo from first trimester to delivery in the original study. No intervention in the present follow-up study. Main Outcomes and Measures Main outcome measure was weight gain in the follow-up period. Weight, body mass index (BMI), waist and hip circumferences, and blood pressure (BP) were registered. Body composition was assessed by bioelectrical impedance analysis, and fasting lipids, glucose, and insulin were analyzed. Results Of 239 invited women, 131 (55%) participated in the follow-up. Weight gain was similar in women given metformin (2.1 ± 10.5 kg) and women given placebo (1.8 ± 11.2 kg) at 7.7 years' follow-up after pregnancy (P = 0.834). No difference was found in BMI, waist/hip ratio, BP, body composition, lipids, glucose and insulin levels, or prevalence of metabolic syndrome at follow-up between those treated with metformin and those treated with placebo during pregnancy. Conclusion Metformin treatment during pregnancy did not influence the metabolic profile in women with PCOS at 7.7 years of follow-up. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://portal.findresearcher.sdu.dk/da/publications/81fc7a35-1e2a-4cb8-9b18-d8961f6e4f11 |
| DOI: | 10.1210/jc.2018-00485 |
| الاتاحة: | https://portal.findresearcher.sdu.dk/da/publications/81fc7a35-1e2a-4cb8-9b18-d8961f6e4f11 https://doi.org/10.1210/jc.2018-00485 https://findresearcher.sdu.dk/ws/files/140659276/Does_metformin_treatment_during_pregnancy_modify_future_metabolic_profile_in_women_with_PCOS.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1D0E0A93 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1210/jc.2018-00485 |
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