التفاصيل البيبلوغرافية
| العنوان: |
Increased plasma levels of the mature and intermediate forms of adrenomedullin in obesity |
| المؤلفون: |
野村, 郁夫, 24894, ノムラ, イクオ, Nomura, Ikuo, Kato, Johji, 24897, 加藤, 丈司, 20274780, カトウ, ジヨウジ, 渡嘉敷, 真理子, 24898, トカシキ, マリコ, Tokashiki, Mariko, 北村, 和雄, キタムラ, カズオ, 50204912, Kitamura, Kazuo |
| بيانات النشر: |
Elsevier |
| سنة النشر: |
2009 |
| المجموعة: |
University of Miyazaki: Dspace |
| مصطلحات موضوعية: |
Body mass index, Insulin sensitivity, Metabolic disorder |
| الوصف: |
Adrenomedullin （AM） is a cardiovascular protective peptide produced in various organs and tissues including adipose tissue. In the present study, we measured the plasma AM levels of subjects with or without obesity by two assay methods to separately evaluate the biologically active AM–NH_2 and the intermediate form of AM–glycine （AM–Gly）. We measured the total AM and AM–NH_2 levels of plasma in 52 obese and 172 non-obese residents of a Japanese community, who received regular health check-ups and had no overt cardiovascular disease. AM–Gly values were obtained by subtracting AM–NH_2 levels from those of total AM. Both the AM–NH_2 and AM–Gly levels of the subjects with obesity were higher than those without obesity, and significant relationships were noted between body mass index （BMI） and the plasma levels of the two molecular forms of AM in a simple regression analysis. Moreover, the significant factors identified by multivariate analyses were BMI and serum triglyceride for AM–NH_2 and diastolic blood pressure, insulin, high-density lipoprotein-cholesterol, and plasma renin activity for AM–Gly. These results suggest active roles for the two molecular forms of AM in metabolic disorders associated with obesity in subjects without overt cardiovascular disease. ; Citation: Nomura I, Kato J, Tokashiki M, Kitamura K. Increased plasma levels of the mature and intermediate forms of adrenomedullin in obesity. Regul Pept. 2009 Nov 27;158(1-3):127-31. doi:10.1016/j.regpep.2009.08.003. Epub 2009 Aug 23. PMID: 19706311. ; journal article |
| نوع الوثيقة: |
other/unknown material |
| اللغة: |
English |
| تدمد: |
01670115 |
| Relation: |
Regulatory Peptides; 158; 127–131; http://hdl.handle.net/10458/5469 |
| الاتاحة: |
http://hdl.handle.net/10458/5469
https://miyazaki-u.repo.nii.ac.jp/records/4620 |
| Rights: |
metadata only access |
| رقم الانضمام: |
edsbas.1CE426E3 |
| قاعدة البيانات: |
BASE |