التفاصيل البيبلوغرافية
| العنوان: |
Comparative Metabolomic Study of Drosophila Species with Different Lifespans |
| المؤلفون: |
Dmitry L. Maslov, Nadezhda V. Zemskaya, Oxana P. Trifonova, Steven Lichtenberg, Elena E. Balashova, Andrey V. Lisitsa, Alexey A. Moskalev, Petr G. Lokhov |
| المصدر: |
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12873 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2021 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
metabolomics, metabolome profiling, direct mass spectrometry, longevity, aging, fruit fly, Drosophila |
| جغرافية الموضوع: |
agris |
| الوصف: |
The increase in life expectancy, leading to a rise in the proportion of older people, is accompanied by a prevalence of age-related disorders among the world population, the fight against which today is one of the leading biomedical challenges. Exploring the biological insights concerning the lifespan is one of the ways to provide a background for designing an effective treatment for the increase in healthy years of life. Untargeted direct injection mass spectrometry-based metabolite profiling of 12 species of Drosophila with significant variations in natural lifespans was conducted in this research. A cross-comparison study of metabolomic profiles revealed lifespan signatures of flies. These signatures indicate that lifespan extension is associated with the upregulation of amino acids, phospholipids, and carbohydrate metabolism. Such information provides a metabolome-level view on longevity and may provide a molecular measure of organism age in age-related studies. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Molecular Pathology, Diagnostics, and Therapeutics; https://dx.doi.org/10.3390/ijms222312873 |
| DOI: |
10.3390/ijms222312873 |
| الاتاحة: |
https://doi.org/10.3390/ijms222312873 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.1CC76E5A |
| قاعدة البيانات: |
BASE |