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Cardiac biomarkers for detection of coronary artery disease in the community

التفاصيل البيبلوغرافية
العنوان: Cardiac biomarkers for detection of coronary artery disease in the community
المؤلفون: Lind, Lars, Alfredsson, Joakim, Andersson, Jonas S. O., Andersson, Therese, Bergström, Göran, Ekblom, Örjan, Fagman, Erika, Fall, Tove, Hagström, Emil, Isholth, Hannes Holm, Janzon, Magnus, Jernberg, Tomas, Katsoularis, Ioannis, Leander, Karin, Leósdóttir, Margrét, Magnusson, Martin, Malinovschi, Andrei, Rosengren, Annika, Smith, J. Gustav, Spaak, Jonas, Svensson, Per, Söderberg, Stefan, Östgren, Carl Johan, Engström, Gunnar
بيانات النشر: Gymnastik- och idrottshögskolan, GIH, Institutionen för fysisk aktivitet och hälsa
Department of Medical Sciences, Clinical Epidemiology, Uppsala University, Uppsala, Sweden
Department of Cardiology, Department of Health, Medicine and Caring Sciences, Unit of Cardiovascular Sciences, Linköping University, Linköping, Sweden.
Department of Public Health and Clinical Medicine, Skellefteå Research Unit, Umeå University, Umeå, Sweden.
Department of Public Health and Clinical Medicine, Section of Medicine, Umeå University, Umeå, Sweden.
Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Region Västra Götaland, Department of Clinical Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Region Västra Götaland, Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.
Department of Medical Sciences, Cardiology and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.; Department of Cardiology, Skåne University Hospital, Malmö, Sweden.
Department of Clinical Sciences, Danderyd University Hospital, Karolinska Institute, Stockholm, Sweden.
Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.; Department of Cardiology, Skåne University Hospital, Malmö, Sweden.; Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa.; Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden.
Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden.
Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Medicine Geriatrics and Emergency Medicine, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden.
Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Cardiology, Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden; Wallenberg Center for Molecular Medicine, Lund University Diabetes Center, Lund university, Lund, Sweden; Region Västra Götaland, Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden
Department of Clinical Sciences, Danderyd University Hospital, Karolinska Institute, Stockholm, Sweden
Department of Clinical Science and Education, Karolinska Institute, Södersjukhuset, Stockholm, Sweden; Department of Cardiology, Södersjukhuset, Stockholm, Sweden
Department of Public Health and Clinical Medicine, Section of Medicine, Umeå University, Umeå, Sweden
CMIV Centre of Medical Image Science and Visualization, Linköping University, Linköping, Sweden; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden
Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
سنة النشر: 2024
المجموعة: GIH Publikationsdatabas (DiVA) / The Swedish School of Sport and Health Science
مصطلحات موضوعية: Coronary atherosclerosis, Epidemiology, NT-proBNP, Population, Troponin, Cardiac and Cardiovascular Systems, Kardiologi
الوصف: To investigate whether coronary artery disease (CAD) burden is associated with plasma levels of the myocardial biomarkers Troponin I (TropI) and NT-proBNP in a large population-based sample using a cross-sectional design. Coronary computerized tomography (CT) angiography was performed in 25,859 subjects without a history of atherosclerotic disease from SCAPIS study (age 50-65, 52% women). TropI and NT-proBNP were measured in plasma. Segment involvement score (SIS) was the primary exposure and TropI the primary outcome. Both SIS and coronary artery calcium score, were associated with TropI levels following adjustment for age, sex and multiple confounders (p < 0.001), with similar relationships in men and women. Proximal segments from all three coronary arteries were related to TropI levels independently of one another. Adding TropI to traditional risk factors marginally increased discrimination of atherosclerosis as compared to risk factors alone (C-statistics + 0.0005, p = 0.014). SIS was related also to NT-proBNP levels, mainly in men, but with lower estimates than TropI. The burden of CAD was related to TropI levels in both men and women. All three major coronary arteries contributed to this relationship. Adding TropI to traditional risk factors resulted in only marginally improved discrimination of coronary atherosclerosis.
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
Relation: Scientific Reports, 2024, 14:1; PMID 39681613
DOI: 10.1038/s41598-024-82777-x
الاتاحة: http://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-8441
https://doi.org/10.1038/s41598-024-82777-x
Rights: info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.1C8D3E8D
قاعدة البيانات: BASE
الوصف
DOI:10.1038/s41598-024-82777-x