Academic Journal
Utility of Direct Pancreatic Function Testing in Children
| العنوان: | Utility of Direct Pancreatic Function Testing in Children |
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| المؤلفون: | Alfaro Cruz Ligia, Párniczky Andrea, Mayhew Allison, Hornung Lindsey N., Lin Tom K., Palermo Joseph J., Jackson Kimberly, Maisam Abu-El-Haija |
| سنة النشر: | 2017 |
| المجموعة: | University of Szeged: SZTE Repository of Publications / SZTE Publicatio Repozitórium |
| مصطلحات موضوعية: | 03.02. Klinikai orvostan |
| الوصف: | OBJECTIVES: Exocrine pancreatic insufficiency (EPI) can have a significant impact on a child's growth and nutrition. Our aim was to evaluate the utility of direct endoscopic pancreatic function testing (ePFT) in pediatrics. METHODS: A single-center retrospective chart review was performed of children who underwent ePFT from December 2007 through February 2015. Endoscopic pancreatic function testings were performed by 1 of 2 methods: (1) intravenous cholecystokinin, followed by the collection of a single duodenal aspirate at 10 minutes, or (2) intravenous cholecystokinin or secretin, followed by the collection of 3 duodenal aspirates at a 5, 10, and 15 minutes. Samples were tested for pH and enzyme activities. RESULTS: A total of 508 ePFTs were performed (481 single-sample tests, 27 multiple-sample tests). Based on the multiple-sample group, enzyme levels for chymotrypsin, amylase, and lipase peaked at 5 minutes, followed by a decrease in activity over time. Exocrine pancreatic sufficiency was identified in 373 (73.4%) and EPI in 93 (18.3%). Exocrine pancreatic sufficiency analysis found all pancreatic enzyme activities significantly increase with age: trypsin, chymotrypsin, amylase, and lipase, (P < 0.05). CONCLUSIONS: Endoscopic pancreatic function testing can be used in the evaluation of EPI in children. Normative data suggest that pancreatic enzyme activities mature with age. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | http://publicatio.bibl.u-szeged.hu/23935/1/Cruz.pdf; Alfaro Cruz Ligia; Párniczky Andrea; Mayhew Allison; Hornung Lindsey N.; Lin Tom K.; Palermo Joseph J.; Jackson Kimberly; Maisam Abu-El-Haija: Utility of Direct Pancreatic Function Testing in Children. PANCREAS, 46 (2). pp. 177-182. ISSN 0885-3177 (2017) |
| DOI: | 10.1097/MPA.0000000000000724 |
| الاتاحة: | http://publicatio.bibl.u-szeged.hu/23935/ http://publicatio.bibl.u-szeged.hu/23935/1/Cruz.pdf https://doi.org/10.1097/MPA.0000000000000724 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1C87511A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/MPA.0000000000000724 |
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