Academic Journal
Double hydrophilic block copolymers self-assemblies in biomedical applications
| العنوان: | Double hydrophilic block copolymers self-assemblies in biomedical applications |
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| المؤلفون: | El Jundi, Ayman, Buwalda, Sytze, Bakkour, Y., Garric, Xavier, Nottelet, Benjamin |
| المساهمون: | Institut des Biomolécules Max Mousseron Pôle Chimie Balard (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Faculty of Sciences Lebanese University, الجامعة اللبنانية بيروت = Lebanese University Beirut = Université libanaise Beyrouth (LU / ULB), Centre de Mise en Forme des Matériaux (CEMEF), Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 0001-8686 ; Advances in Colloid and Interface Science ; https://hal.science/hal-03097549 ; Advances in Colloid and Interface Science, 2020, 283, pp.102213. ⟨10.1016/j.cis.2020.102213⟩. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2020 |
| المجموعة: | Université de Montpellier: HAL |
| مصطلحات موضوعية: | Double-hydrophilic block copolymers, pH-responsive polymers, drug delivery systems, polyion complex micelles, degradable copolymers, [CHIM.POLY]Chemical Sciences/Polymers, [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials, [SDV.SP.PG]Life Sciences [q-bio]/Pharmaceutical sciences/Galenic pharmacology |
| الوصف: | International audience ; Double-hydrophilic block copolymers (DHBCs), consisting of at least two different water-soluble blocks, are an alternative to the classical amphiphilic block copolymers and have gained increasing attention in the field of biomedical applications. Although the chemical nature of the two blocks can be diverse, most classical DHBCs consist of a bioeliminable non-ionic block to promote solubilization in water, like poly(ethylene glycol), and a second block that is more generally a pH-responsive block capable of interacting with another ionic polymer or substrate. This second block is generally non-degradable and the presence of side chain functional groups raises the question of its fate and toxicity, which is a limitation in the frame of biomedical applications. In this review, following a first part dedicated to recent examples of non-degradable DHBCs, we focus on the DHBCs that combine a biocompatible and bioeliminable non-ionic block with a degradable functional block including polysaccharides, polypeptides, polyesters and other miscellaneous polymers. Their use to design efficient drug delivery systems for various biomedical applications through stimuli-dependent self-assembly is discussed along with the current challenges and future perspectives for this class of copolymers. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | hal-03097549; https://hal.science/hal-03097549; https://hal.science/hal-03097549/document; https://hal.science/hal-03097549/file/Adv%20Colloid%20Interf%20Sci%20_%20El%20Jundi%20Review.pdf |
| DOI: | 10.1016/j.cis.2020.102213 |
| الاتاحة: | https://hal.science/hal-03097549 https://hal.science/hal-03097549/document https://hal.science/hal-03097549/file/Adv%20Colloid%20Interf%20Sci%20_%20El%20Jundi%20Review.pdf https://doi.org/10.1016/j.cis.2020.102213 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.1C6936B1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.cis.2020.102213 |
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