Academic Journal
Pituitary adenoma in patients with multiple endocrine neoplasia type 1: a cohort study.
| العنوان: | Pituitary adenoma in patients with multiple endocrine neoplasia type 1: a cohort study. |
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| المؤلفون: | Le Bras, Maelle, Leclerc, Hélène, Rousseau, Olivia, Goudet, Pierre, Cuny, Thomas, Castinetti, Frederic, Bauters, Catherine, Chanson, Philippe, Tabarin, Antoine, Gaujoux, Sebastien, Christin-Maitre, Sophie, Ruszniewski, Philippe, Borson-Chazot, Francoise, Guilhem, Isabelle, Caron, Philippe, Goichot, Bernard, Beckers, Albert, Delemer, Brigitte, Raingeard, Isabelle, Vergès, Bruno, Smati, Sarra, Wargny, Matthieu, Cariou, Bertrand, Hadjadj, Samy |
| المصدر: | European Journal of Endocrinology, 185 (6), 863-873 (2021-11-26) |
| بيانات النشر: | BioScientifica |
| سنة النشر: | 2021 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | Adult, Cohort Studies, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Endocrine Neoplasia Type 1/pathology, Pituitary Neoplasms/pathology, Retrospective Studies, Human health sciences, Endocrinology, metabolism & nutrition, Sciences de la santé humaine, Endocrinologie, métabolisme & nutrition |
| الوصف: | peer reviewed ; OBJECTIVE: Pituitary adenoma (PA) is one of the three major components of multiple endocrine neoplasia type 1 (MEN1). Recent studies have suggested that MEN1-associated PAs are less aggressive than initially estimated. We propose an analysis of the outcome of PAs with a standard of care treatment in a nationwide cohort of MEN1 patients. DESIGN: Retrospective observational nationwide cohort study using the MEN1 patient registry from the French Group of Endocrine Tumours (GTE). METHODS: The GTE database population consists of 1435 patients with MEN1. This analysis focused on 551 patients recruited after 2000 with at least 3 years of follow-up. The study outcome was tumour progression of PA defined by an increase in Hardy classification (HC) during follow-up according to referring physician regular reports. RESULTS: Among 551 MEN1 patients (index and related), 202 (36.7%) had PA, with 114 (56.4%) diagnosed by MEN1-related screening. PAs were defined according to HC as microadenoma (grade I) in 117 cases (57.9%), macroadenoma in 59 (29.2%) with 20 HC grade II and 39 HC grades III-IV and unspecified in 26 (12.8%). They were prolactinomas in 92 cases (45.5%) and non-secreting in 73 (36.1%). After a median follow-up of 3 years among the 137 patients with HC grades I-II, 4 patients (2.9%) presented tumour progression. CONCLUSION: PAs in patients with MEN1 are less aggressive than previously thought. Tumour progression is rare with a standard of care monitoring and treatment, especially in related patients who mostly present non-secreting microadenoma. MRI monitoring for asymptomatic MEN1 patients should be reduced accordingly. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0804-4643 1479-683X |
| Relation: | urn:issn:0804-4643; urn:issn:1479-683X; https://orbi.uliege.be/handle/2268/303882; info:hdl:2268/303882; info:pmid:34636744 |
| DOI: | 10.1530/EJE-21-0630 |
| الاتاحة: | https://orbi.uliege.be/handle/2268/303882 https://orbi.uliege.be/bitstream/2268/303882/1/EuropeanJournalofEndo-LeBras2021.pdf https://doi.org/10.1530/EJE-21-0630 |
| Rights: | open access ; http://purl.org/coar/access_right/c_abf2 ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1C68B15B |
| قاعدة البيانات: | BASE |
| تدمد: | 08044643 1479683X |
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| DOI: | 10.1530/EJE-21-0630 |