Academic Journal
Clonal dynamics of haematopoiesis across the human lifespan.
| العنوان: | Clonal dynamics of haematopoiesis across the human lifespan. |
|---|---|
| المؤلفون: | Mitchell, Emily, Spencer Chapman, Michael, Williams, Nicholas, Dawson, Kevin J, Mende, Nicole, Calderbank, Emily F, Jung, Hyunchul, Mitchell, Thomas, Coorens, Tim HH, Spencer, David H, Machado, Heather, Lee-Six, Henry, Davies, Megan, Hayler, Daniel, Fabre, Margarete A, Mahbubani, Krishnaa, Abascal, Federico, Cagan, Alex, Vassiliou, George S, Baxter, Joanna, Martincorena, Inigo, Stratton, Michael R, Kent, David G, Chatterjee, Krishna, Parsy, Kourosh Saeb, Green, Anthony R, Nangalia, Jyoti, Laurenti, Elisa, Campbell, Peter J |
| بيانات النشر: | Springer Science and Business Media LLC //doi.org/10.1038/s41586-022-04786-y Nature |
| سنة النشر: | 2024 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | Adolescent, Adult, Aged, 80 and over, Aging, Child, Preschool, Clonal Hematopoiesis, Clone Cells, Female, Hematologic Neoplasms, Hematopoietic Stem Cells, Humans, Infant, Newborn, Longevity, Male, Middle Aged, Multipotent Stem Cells, Young Adult |
| الوصف: | Acknowledgements: This work was supported by the WBH Foundation. Investigators at the Sanger Institute are supported by a core grant from the Wellcome Trust. P.J.C. was a Wellcome Trust Senior Clinical Fellow (WT088340MA) until 2020. N.M. was supported by a DFG Research Fellowship (ME 5209/1-1). Work in the D.G.K. laboratory is supported by a Bloodwise Bennett Fellowship (15008), a Cancer Research UK Programme Foundation Award (DCRPGF\100008), and a European Research Council Starting Grant (ERC-2016-STG–715371). Work in the A.R.G. laboratory is supported by the Wellcome Trust, Bloodwise, Cancer Research UK, the Kay Kendall Leukaemia Fund, and the Leukemia and Lymphoma Society of America. Work in the E.L. laboratory is supported by a Wellcome Trust Sir Henry Dale Fellowship, BBSRC and a European Haematology Association Non-Clinical Advanced Research Fellowship. The E.L. and A.R.G. laboratories are supported by a core support grant from the Wellcome Trust and Medical Research Council to the Cambridge Stem Cell Institute. K.M. is supported by the Chan-Zuckerberg Initiative. K.C. is supported by a Wellcome Investigator award (210755/Z/18/Z). We thank the Cambridge Blood and Stem Cell Biobank; the Cambridge Biorepository for Translational Medicine for access to human bone marrow and matched peripheral blood; and the Cambridge NIHR BRC Cell Phenotyping Hub for their flow cytometry services and advice. We acknowledge further assistance from the National Institute for Health Research Cambridge Biomedical Research Centre and the Cambridge Experimental Cancer Medicine Centre. We are grateful to the donors, families of donors and the Cambridge Biorepository for Translational Medicine for the gift of tissues. We thank T. Ley for his help with analysis of AML genomes. For the purpose of Open Access, the author has applied a CC-BY public copyright license to any Author Accepted Manuscript version arising from this submission. This research was supported by the NIHR Cambridge Biomedical Research Centre (BRC-1215-20014). The ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text/xml; application/zip; application/pdf |
| اللغة: | English |
| Relation: | https://www.repository.cam.ac.uk/handle/1810/364980 |
| الاتاحة: | https://www.repository.cam.ac.uk/handle/1810/364980 |
| Rights: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.1C136A19 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |