التفاصيل البيبلوغرافية
| العنوان: |
Improvement in symptoms and cochlear flow with pycnogenol in patients with Meniere's disease and tinnitus |
| المؤلفون: |
R. Luzzi, G. Belcaro, S. Hu, M. Dugall, M. Hosoi, M. Cacchio, M. Corsi, E. Ippolito |
| المساهمون: |
R. Luzzi, G. Belcaro, S. Hu, M. Dugall, M. Hosoi, M. Cacchio, E. Ippolito, M. Corsi |
| سنة النشر: |
2014 |
| المجموعة: |
The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: |
Cochlea, Ear, inner, Meniere disease, Perfusion, Pycnogenol, Tinnitu, Ultrasonography, Doppler, Duplex, Settore MED/22 - Chirurgia Vascolare |
| الوصف: |
AIM: The aim of this supplement registry was to evaluate the efficacy of the Pycnogenol® in improving cochlear flow and symptoms in a 6-month follow-up for patients with Meniere's disease (MD), tinnitus and cochlear hypoperfusion. METHODS: Main signs/symptoms were considered: Spontaneous vertigo, positional vertigo, hearing loss, tinnitus, pressure in the ear, unsteady gait, associated clinical problems, alterations in daily life. All subjects were managed with the best available management (BM); one group used the supplement Pycnogenol (150 mg/day). Cochlear flow and tinnitus were also evaluated. Out of 120 patients incuded in the registry, 55 used Pycnogenol and 52 (controls) were managed only with BM. RESULTS: There was a more significant improvement in all registry items at 3 and 6 months in the Pycnogenol group (P<0.05). The number of lost working days was lower in the Pycnogenol group. At 3 months, 45.4% of subjects using Pycnogenol were completely asymptomatic in comparison with 23.07% of controls. At 6 months 87.3% of the Pycnogenol subjects were asymptomatic compared with 34.6% of controls. Cochlear flow velocity was significantly better (higher flow, higher diastolic component) in the Pycnogenol group (P<0.05). The subjective tinnitus scale decreased in both groups (P<0.05); the decrease was more significant in Pycnogenol subjects (P<0.05) at 3 and 6 months. CONCLUSION: Symptoms of Meniere's disease, flow at cochlear level and tinnitus improved in Pycnogenol subjects in comparison with best management. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/24988090; info:eu-repo/semantics/altIdentifier/wos/WOS:000342185200007; volume:105; issue:3; firstpage:245; lastpage:254; numberofpages:10; journal:MINERVA MEDICA; http://hdl.handle.net/2434/260832; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84906568667 |
| الاتاحة: |
http://hdl.handle.net/2434/260832 |
| رقم الانضمام: |
edsbas.1C0A9280 |
| قاعدة البيانات: |
BASE |