Academic Journal
Emerging roles of RNA methylation in gastrointestinal cancers
| العنوان: | Emerging roles of RNA methylation in gastrointestinal cancers |
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| المؤلفون: | Xie, Shanshan, Chen, Wenwen, Chen, Kanghua, Chang, Yongxia, Yang, Feng, Lin, Aifu, Shu, Qiang, Zhou, Tianhua, Yan, Xiaoyi |
| المساهمون: | Young Scientists Fund, National Natural Science Foundation of China |
| المصدر: | Cancer Cell International ; volume 20, issue 1 ; ISSN 1475-2867 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2020 |
| الوصف: | RNA methylation has emerged as a fundamental process in epigenetic regulation. Accumulating evidences indicate that RNA methylation is essential for many biological functions, and its dysregulation is associated with human cancer progression, particularly in gastrointestinal cancers. RNA methylation has a variety of biological properties, including N 6-methyladenosine (m6A), 2- O -dimethyladenosine (m6Am), N 1-methyladenosine (m1A), 5-methylcytosine (m5C) and 7-methyl guanosine (m7G). Dynamic and reversible methylation on RNA is mediated by RNA modifying proteins called “writers” (methyltransferases) and “erasers” (demethylases). “Readers” (modified RNA binding proteins) recognize and bind to RNA methylation sites, which influence the splicing, stability or translation of modified RNAs. Herein, we summarize the biological functions and mechanisms of these well-known RNA methylations, especially focusing on the roles of m6A in gastrointestinal cancer development. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1186/s12935-020-01679-w |
| DOI: | 10.1186/s12935-020-01679-w.pdf |
| DOI: | 10.1186/s12935-020-01679-w/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1186/s12935-020-01679-w http://link.springer.com/content/pdf/10.1186/s12935-020-01679-w.pdf http://link.springer.com/article/10.1186/s12935-020-01679-w/fulltext.html |
| Rights: | http://creativecommons.org/licenses/by/4.0/ ; http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.1C08FA72 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12935-020-01679-w |
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