Academic Journal
Gold(I)-catalyzed divergent and diastereoselective synthesis of azepines by ammoniumation/ring-expansion reactions
| العنوان: | Gold(I)-catalyzed divergent and diastereoselective synthesis of azepines by ammoniumation/ring-expansion reactions |
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| المؤلفون: | Pertschi, Romain, Miaskiewicz, Solène, Kern, Nicolas, Weibel, Jean-Marc, Pale, Patrick, Blanc, Aurélien |
| المساهمون: | Institut de Chimie de Strasbourg, Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC) |
| المصدر: | ISSN: 2667-1093 ; Chem Catalysis ; https://hal.archives-ouvertes.fr/hal-03376044 ; Chem Catalysis, Elsevier, 2021, 1 (1), pp.129-145. ⟨10.1016/j.checat.2021.02.004⟩. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2021 |
| المجموعة: | Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
| مصطلحات موضوعية: | Ring Expansion, Azepines, Azetidines, Ammoniumation, Gold(I), Catalysis, [CHIM.ORGA]Chemical Sciences/Organic chemistry, [CHIM.CATA]Chemical Sciences/Catalysis |
| الوصف: | International audience ; Azepines are fragments found in natural products possessing relevant biological activities. Our method provides access to multiple azepine derivatives from simple azetidine derivatives in the presence of a gold catalyst. Small variations on the starting material conduct to different reaction cascades whose mechanisms have been thoroughly studied to explain and control the observed selectivity. This journey led to the discovery of original azepine scaffolds along the way, whose biological activity remains to be studied. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | hal-03376044; https://hal.archives-ouvertes.fr/hal-03376044; https://hal.archives-ouvertes.fr/hal-03376044/document; https://hal.archives-ouvertes.fr/hal-03376044/file/Draft%20Chem%20Catal.pdf |
| DOI: | 10.1016/j.checat.2021.02.004 |
| الاتاحة: | https://hal.archives-ouvertes.fr/hal-03376044 https://hal.archives-ouvertes.fr/hal-03376044/document https://hal.archives-ouvertes.fr/hal-03376044/file/Draft%20Chem%20Catal.pdf https://doi.org/10.1016/j.checat.2021.02.004 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.1BBDAEF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.checat.2021.02.004 |
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