Academic Journal
IgG3‐Mediated Enhancement of the Antibody Response is Normal in FcγRI‐Deficient Mice
| العنوان: | IgG3‐Mediated Enhancement of the Antibody Response is Normal in FcγRI‐Deficient Mice |
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| المؤلفون: | Hjelm, F., Carlsson, F., Verbeek, S., Heyman, B. |
| المصدر: | Scandinavian Journal of Immunology ; volume 62, issue 5, page 453-461 ; ISSN 0300-9475 1365-3083 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2005 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Antibodies, administered together with their specific antigen, can feedback‐regulate antibody responses to this antigen. IgG1, IgG2a and IgG2b enhance antibody responses to soluble protein antigens. This effect is primarily mediated by FcRs as enhancement is impaired in FcRγ –/– mice, reported to lack FcγRI and FcγRIII because of deletion of the common FcRγ chain. Also IgG3 can enhance antibody responses. However, this effect is unperturbed in FcRγ –/– mice but severely impaired in complement‐depleted animals and in animals lacking complement receptor 1 and 2. Although this argues against involvement of FcγRs, FcRγ –/– mice may express one‐fifth of the normal levels of FcγRI and, in addition, FcγRI has been suggested to bind IgG3. We re‐investigated the dependence of IgG3‐mediated enhancement on FcγRs using a mouse strain selectively lacking FcγRI and found that IgG3‐mediated enhancement is completely normal. Unlike IgE and IgG2a, which are both thought to enhance T‐cell proliferation via FcR‐mediated antigen presentation, IgG3 was a poor enhancer of T‐cell proliferation both in vivo and in vitro . These findings argue against a significant involvement of FcγRs in IgG3‐mediated enhancement of antibody responses and support our previous conclusion that complement plays a major role. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/j.1365-3083.2005.01684.x |
| الاتاحة: | http://dx.doi.org/10.1111/j.1365-3083.2005.01684.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-3083.2005.01684.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-3083.2005.01684.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.1BA2A234 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1365-3083.2005.01684.x |
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