Academic Journal
Role for ATXN1, ATXN2, and HTT intermediate repeats in frontotemporal dementia and Alzheimer's disease
| العنوان: | Role for ATXN1, ATXN2, and HTT intermediate repeats in frontotemporal dementia and Alzheimer's disease |
|---|---|
| المؤلفون: | Rosas, I, Martínez, C, Clarimón, J, Lleó, A, Illán-Gala, I, Dols-Icardo, O, Borroni, B, Almeida, MR, van der Zee, J, Van Broeckhoven, C, Bruni, AC, Anfossi, M, Bernardi, L, Maletta, R, Serpente, M, Galimberti, D, Scarpini, E, Rossi, G, Caroppo, P, Benussi, L, Ghidoni, R, Binetti, G, Nacmias, B, Sorbi, S, Piaceri, I, Bagnoli, S, Antonell, A, Sánchez-Valle, R, De la Casa-Fages, B, Grandas, F, Diez-Fairen, M, Pastor, P, Ferrari, R, Álvarez, V, Menéndez-González, M |
| المصدر: | Neurobiology of Aging , 87 139.e1-139.e7. (2020) |
| سنة النشر: | 2020 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | CAG repeats, Intermediate alleles, Neurodegeneration, Tauopathies |
| الوصف: | We analyzed the frequency of intermediate alleles (IAs) in the ATXN1, ATXN2, and HTT genes in several neurodegenerative diseases. The study included 1126 patients with Alzheimer's disease (AD), 440 patients with frontotemporal dementia (FTD), and 610 patients with Parkinson's disease. In all cohorts, we genotyped ATXN1 and ATXN2 CAG repeats. In addition, in the FTD cohort, we determined the number of HTT CAG repeats. The frequency of HTT IAs was higher in patients with FTD (6.9%) versus controls (2.9%) and in the C9orf72 expansion noncarriers (7.2%) versus controls (2.9%), although the difference was nonsignificant after correction for multiple testing. Compared with controls, progressive nonfluent aphasia (PNFA) groups showed a significantly higher frequency of HTT IAs (13.6% vs. 2.9% controls). For the ATXN2 gene, we observed an increase in IA frequency in AD cases (AD 4.1% vs. controls 1.8%) and in the behavioral FTD group (4.8% vs. 1.8%). For the ATXN1 gene, we found a significant increase of IAs in patients with PNFA (18.6%) versus controls (6.7%). In conclusion, our work suggests that the HTT and ATXN1 IAS may contribute to PNFA pathogenesis and point to a link between ATXN2 IAS and AD. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://discovery.ucl.ac.uk/id/eprint/10089351/3/Ferrari_ATXN1-2-HTT_Pre-publ-Draft.pdf; https://discovery.ucl.ac.uk/id/eprint/10089351/ |
| الاتاحة: | https://discovery.ucl.ac.uk/id/eprint/10089351/3/Ferrari_ATXN1-2-HTT_Pre-publ-Draft.pdf https://discovery.ucl.ac.uk/id/eprint/10089351/ |
| Rights: | open |
| رقم الانضمام: | edsbas.1B93C96A |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |