Dissertation/ Thesis
Motor signs and psychotic diseases : anual dexterity as a predictor of disease's progression toward schizophrenia ; Signes moteurs et maladies psychotiques : la dextérité manuelle comme marqueur de la progression de la maladie vers la schizophrénie
| العنوان: | Motor signs and psychotic diseases : anual dexterity as a predictor of disease's progression toward schizophrenia ; Signes moteurs et maladies psychotiques : la dextérité manuelle comme marqueur de la progression de la maladie vers la schizophrénie |
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| المؤلفون: | Le Boterff, Quentin |
| المساهمون: | Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Université Paris Cité, Påvel Lindberg |
| المصدر: | https://theses.hal.science/tel-04638839 ; Psychologie. Université Paris Cité, 2023. Français. ⟨NNT : 2023UNIP7170⟩. |
| بيانات النشر: | HAL CCSD |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Schizophrenia, First Episode Psychosis, Autism Spectrum Disorders, Manual dexterity, Neurological Softs Signs, Transcranial Magnetic Stimulation, Schizophrénie, Premier Épisode Psychotique, Troubles du Spectre Autistique, Dextérité manuelle, Signes Neurologiques Mineurs, Stimulation Magnétique Transcrânienne, [SHS.PSY]Humanities and Social Sciences/Psychology, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | Introduction : Schizophrenia is a psychiatric disorder characterized by various symptoms including sensorimotor and cognitive deficits. Like autism spectrum disorders, schizophrenia follows a neurodevelopmental model. The neurodevelopmental burden involved in the development of the disease can be measured through neurological soft signs: subtle deficits in patients' motor skills. The aim of this thesis is to validate the capacity of measures of manual dexterity to measure these deficits in a rapid, quantitative and objective manner in order to identify patients at the early stage of schizophrenia, and to predict their evolution. Method : We have developed a manual dexterity assessment tool in the form of a tablet application. First, we studied the validity and the reliability of this tool in a group of 88 healthy subjects. In a second study, 20 patients with first episode psychosis (FEP), 20 with chronic schizophrenia (SCZ), and 20 with autism spectrum disorder (ASD) were compared to 20 healthy subjects to test the ability of the tool to classify patients according to their disorder and to compare measurements of manual dexterity to assessments of cortical excitability and inhibition. In a third study still in progress, the symptomatological evolution of patients at the stage of FEP was evaluated at 3 months. Results : The manual dexterity measurements obtained with the tablet tool are reliable measures that can effectively classify the different psychiatric disorders, in particular FEP patients who present more deficits in manual dexterity than the SCZ and ASD groups. Deficits are particularly pronounced in mental rotation and rhythm tapping tasks of our tablet evaluation. Similare differential alterations across patients groups were found in the neurophysiological measurement of intracortical inhibition. The task assessing online motor control, however, presents a higher deficit in SCZ patients than in FEP, suggesting that this measure has the highest potential to capture the symptomatological evolution of ... |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| اللغة: | French |
| Relation: | NNT: 2023UNIP7170; tel-04638839; https://theses.hal.science/tel-04638839; https://theses.hal.science/tel-04638839/document; https://theses.hal.science/tel-04638839/file/va_Le_boterff_Quentin.pdf |
| الاتاحة: | https://theses.hal.science/tel-04638839 https://theses.hal.science/tel-04638839/document https://theses.hal.science/tel-04638839/file/va_Le_boterff_Quentin.pdf |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.1B8C7C9F |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |