Academic Journal
Helper T cell recognition of respiratory syncytial virus in mice
| العنوان: | Helper T cell recognition of respiratory syncytial virus in mice |
|---|---|
| المؤلفون: | Peter J. M. Openshaw, Roy M. Pemberton, L. Andrew Ball I, Ga Ll W. Wertz, Brig Itte A |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://vir.sgmjournals.org/content/69/2/305.full.pdf. |
| سنة النشر: | 1988 |
| المجموعة: | CiteSeerX |
| الوصف: | In this study we aimed to define the protein and viral subtype specificities of helper Th cells to respiratory syncytial virus (RSV). BALB/c mice were primed by infection with RSV, or with vaccinia viruses (VV) containing enes encoding several individual RSV proteins. Priming for Th cell memory was assayed by stimulating spleen cells in vitro with different RSV isolates and measuring RSV-specific interleukin 2 (IL-2) release by T cells into supernatants using an IL-2-dependent CTLL cell, line. Splenocytes from mice primed intranasally with RSV exhibited RSV-specific Th cell memory, whereas those from unprimed mice did not. Th cell recognition was in part specific to the strain of RSV used in priming and in part cross-reactive b tween RSV strains. Intraperitoneal priming with RSV fusion protein-expressing VV or nucleopro-tein-expressing VV induced a stronger RSV-specific Th cell response than the attachment glycoprotein-expressing VV which produced only slight Th recognition. No Th cell recognition of two non-structural proteins (1A and 1 B) could be demonstrated. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.628.3759; http://vir.sgmjournals.org/content/69/2/305.full.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.628.3759 http://vir.sgmjournals.org/content/69/2/305.full.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.1B687AF |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |