Academic Journal
Clinical markers of atrial abnormality as predictors of cardioembolic events in patients with embolic stroke of undetermined source
| العنوان: | Clinical markers of atrial abnormality as predictors of cardioembolic events in patients with embolic stroke of undetermined source |
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| المؤلفون: | Guichard, J B, Vial, M, Hean, V, Da Costa, A, Camdessanche, J P, Garnier, P |
| المصدر: | Europace ; volume 25, issue Supplement_1 ; ISSN 1099-5129 1532-2092 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Physiology (medical), Cardiology and Cardiovascular Medicine |
| الوصف: | Funding Acknowledgements Type of funding sources: Private company. Main funding source(s): Unrestrictive grant for fellowship support - Abbot Medical Background Embolic stroke of undetermined source (ESUS) represents 17% of ischemic strokes. The lack of etiology leads to unsuitable treatment, higher stroke recurrence, and death. Several features presume atrial cardiomyopathy (ACM) as a potential etiology of embolism among ESUS population, but its causative role is not steadily grounded. Purpose To assess predictors, focusing on markers of ACM, of diagnosis of a cardioembolic source in ESUS patients during a long-term follow-up. Methods (Figure 1) - This study was an observational, retrospective, monocentric, cohort trial designed to assess predictors of cardioembolic events occurrence in an ESUS population along a 9-year follow-up. 128 ESUS patients who faced an ischemic stroke with a negative extensive etiological assessment from 2009 to 2012 were consecutively included. Upon ESUS diagnosis, clinical, echocardiographic (including transthoracic and transoesophageal echocardiogram), electrocardiographic (ECG), and Holter-ECG features were recorded. The occurrence of atrial fibrillation (AF) and the recurrence of ischemic stroke were registered during follow-up. Diagnosis of a cardioembolic source, a composite outcome, was defined as AF occurrence and/or recurrence of ischemic stroke, for which a cardioembolic cause was diagnosed secondary to the etiologic evaluation. Results (Figure 2) - AF and a cardioembolic source were diagnosed in 13 patients (10.2%) and 17 patients (13.3%) respectively, during the 9-year follow-up. Overall ischemic stroke recurrence was diagnosed in 13 patients (10.2%). Through univariate analyses, age higher than 65 (HR=4.9, p<0.01, 95%CI:1.5-16.1), abnormal P-wave axis (HR=4.3, p=0.01, 95%CI:1.4-13.2), increased PAC burden (HR=6.0, p<0.01, 95%CI:2.0-18.5), left atrial (LA) dilation (HR=6.1, p<0.01, 95%CI:2.0-18.7), and abnormal LA appendage outflow velocity ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/europace/euad122.007 |
| الاتاحة: | http://dx.doi.org/10.1093/europace/euad122.007 https://academic.oup.com/europace/article-pdf/25/Supplement_1/euad122.007/50427926/euad122.007.pdf |
| Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.1B6285A4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/europace/euad122.007 |
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