Academic Journal
MicroRNAs in peripheral artery disease: potential biomarkers and pathophysiological mechanisms
| العنوان: | MicroRNAs in peripheral artery disease: potential biomarkers and pathophysiological mechanisms |
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| المؤلفون: | Ring, Andrew, Ismaeel, Ahmed, Wechsler, Marissa, Fletcher, Emma, Papoutsi, Evlampia, Miserlis, Dimitrios, Koutakis, Panagiotis |
| المساهمون: | National Institute on Aging |
| المصدر: | Therapeutic Advances in Cardiovascular Disease ; volume 16, page 175394472210969 ; ISSN 1753-9447 1753-9455 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2022 |
| الوصف: | Peripheral artery disease (PAD) is a disease of atherosclerosis in the lower extremities. PAD carries a massive burden worldwide, while diagnosis and treatment options are often lacking. One of the key points of research in recent years is the involvement of microRNAs (miRNAs), which are short 20-25 nucleotide single-stranded RNAs that can act as negative regulators of post-transcriptional gene expression. Many of these miRNAs have been discovered to be misregulated in PAD patients, suggesting a potential utility as biomarkers for PAD diagnosis. miRNAs have also been shown to play an important role in many different pathophysiological aspects involved in the initiation and progression of the disease including angiogenesis, hypoxia, inflammation, as well as other cellular functions like cell proliferation and migration. The research on miRNAs in PAD has the potential to lead to a whole new class of diagnostic tools and treatments. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/17539447221096940 |
| الاتاحة: | http://dx.doi.org/10.1177/17539447221096940 http://journals.sagepub.com/doi/pdf/10.1177/17539447221096940 http://journals.sagepub.com/doi/full-xml/10.1177/17539447221096940 |
| Rights: | https://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.1B3F691A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/17539447221096940 |
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