Academic Journal
Post-COVID Complications after Pressure Ulcer Surgery in Patients with Spinal Cord Injury Associate with Creatine Kinase Upregulation in Adipose Tissue
| العنوان: | Post-COVID Complications after Pressure Ulcer Surgery in Patients with Spinal Cord Injury Associate with Creatine Kinase Upregulation in Adipose Tissue |
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| المؤلفون: | Martínez-Torija, Mario, Esteban, Pedro F., Espino-Rodríguez, Francisco Javier, Paniagua-Torija, Beatriz, Molina-Holgado, Eduardo, Ceruelo, Silvia, Barroso-Garcia, Gemma, Arandilla, Alba G., Lopez-Almodovar, Luis F., Arevalo-Martin, Angel, Moreno, Juan Antonio, Garcia-Ovejero, Daniel, Durán Ruiz, María del Carmen, Moreno Luna, Rafael |
| المساهمون: | Biomedicina, Biotecnología y Salud Pública |
| المصدر: | Cells, Vol. 11, Núm. 8 |
| بيانات النشر: | MDPI |
| سنة النشر: | 2022 |
| المجموعة: | RODIN - Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz |
| مصطلحات موضوعية: | COVID-19, SARS-CoV-2, SCI, PU, surgery, adipose tissue, proteomics, CKs, MGCs, autoantibodies |
| الوصف: | The risk of complications following surgical procedures is significantly increased in patients with SARS-CoV-2 infection. However, the mechanisms underlying these correlations are not fully known. Spinal cord injury (SCI) patients who underwent reconstructive surgery for pressure ulcers (PUs) before and during the COVID-19 pandemic were included in this study. The patient's postoperative progression was registered, and the subcutaneous white adipose tissue (s-WAT) surrounding the ulcers was analyzed by proteomic and immunohistochemical assays to identify the molecular/cellular signatures of impaired recovery. Patients with SCI and a COVID-19-positive diagnosis showed worse recovery and severe postoperative complications, requiring reintervention. Several proteins were upregulated in the adipose tissue of these patients. Among them, CKMT2 and CKM stood out, and CKM increased for up to 60 days after the COVID-19 diagnosis. Moreover, CKMT2 and CKM were largely found in MGCs within the s-WAT of COVID patients. Some of these proteins presented post-translational modifications and were targeted by autoantibodies in the serum of COVID patients. Overall, our results indicate that CKMT2, CKM, and the presence of MGCs in the adipose tissue surrounding PUs in post-COVID patients could be predictive biomarkers of postsurgical complications. These results suggest that the inflammatory response in adipose tissue may underlie the defective repair seen after surgery. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2073-4409 |
| Relation: | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI18%2F00427/ES/ESTUDIO PRECLINICO: USO COMBINADO DE CELULAS MADRES%2FPROGENITORAS ENDOTELIALES DERIVADAS DEL TEJIDO ADIPOSO DE LESIONADOS MEDULARES PARA LA REPARACION%2FREGENERACION DE ULCERAS POR PRESION/; info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F00375/ES/NUEVOS MECANISMOS Y DIANAS TERAPEUTICAS IMPLICADAS EN LA PROGRESION DEL DAÑO RENAL EN PATOLOGIAS ASOCIADAS A ACUMULACION DE HEMOGLOBINA/; http://hdl.handle.net/10498/26966 |
| DOI: | 10.3390/cells11081282 |
| الاتاحة: | http://hdl.handle.net/10498/26966 https://doi.org/10.3390/cells11081282 |
| Rights: | Atribución 4.0 Internacional ; http://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1AFF2F5E |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20734409 |
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| DOI: | 10.3390/cells11081282 |