التفاصيل البيبلوغرافية
| العنوان: |
High-Dose Intravenous Steroid Treatment Seems to Have No Long-Term Negative Effect on Bone Mineral Density of Young and Newly Diagnosed Multiple Sclerosis Patients: A Pilot Study |
| المؤلفون: |
George Simeakis, Maria Anagnostouli, Nikolaos Fakas, John Koutsikos, Athanasios Papatheodorou, Konstantinos Chanopoulos, Kwnstantinos Athanasiou, George Papatheodorou, Evangelia Zapanti, Maria Alevizaki, Gregory Kaltsas, Evangelos Terpos |
| المصدر: |
Biomedicines; Volume 11; Issue 2; Pages: 603 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2023 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
multiple sclerosis, glucocorticoids, BMD, cytokines, periostin, 25-hydroxyvitamin D, bone-turnover, osteoporosis |
| الوصف: |
High-dose intravenous steroid treatment (HDIST) represents the first choice of treatment for multiple sclerosis (MS) relapses. Chronic oral glucocorticoid (GC) administration correlates with bone loss whereas data regarding HDIST in MS are still conflicting. Twenty-five newly diagnosed MS patients (NDMSP) (median age: 37 years) were prospectively studied for the effects of HDIST on bone mineral density (BMD) and bone metabolism. Patients received 1000 mg methylprednisolone intravenously every day for 5 days followed by oral prednisolone tapering over 21 days. Bone metabolism indices were determined prior to GC, on days 2, 4, 6, and 90, and at months 6, 12, 18, and 24 post GC therapy. Femoral, lumbar-spine BMD, and whole-body measurement of adipose/lean tissue were assessed prior to GC-administration and then every six months. Ten patients completed the study. N-terminal-propeptide-procollagen-type-1 and bone-specific alkaline phosphatase showed a significant increase at day-90 (p < 0.05). A transient non-significant fall of BMD was observed at 6 months after GC-administration, which subsequently appeared to be restored. We conclude that HDIST seems not to have long-term negative effects on BMD, while the observed transient increase of bone formation markers probably indicates a high bone turnover phase to GC-administration. Additional prospective studies with larger sample size are needed. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Endocrinology and Metabolism Research; https://dx.doi.org/10.3390/biomedicines11020603 |
| DOI: |
10.3390/biomedicines11020603 |
| الاتاحة: |
https://doi.org/10.3390/biomedicines11020603 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.1AAC6629 |
| قاعدة البيانات: |
BASE |