3D reconstructions of WT and Rbp1-/- aortic valves in position within the aortic root.

التفاصيل البيبلوغرافية
العنوان: 3D reconstructions of WT and Rbp1-/- aortic valves in position within the aortic root.
المؤلفون: Rachel Queen, Moira Crosier, Lorraine Eley, Janet Kerwin, Jasmin E. Turner, Jianshi Yu, Ahlam Alqahtani, Tamilvendhan Dhanaseelan, Lynne Overman, Hannah Soetjoadi, Richard Baldock, Jonathan Coxhead, Veronika Boczonadi, Alex Laude, Simon J. Cockell, Maureen A. Kane, Steven Lisgo, Deborah J. Henderson
سنة النشر: 2023
مصطلحات موضوعية: Genetics, Biotechnology, Evolutionary Biology, Developmental Biology, Inorganic Chemistry, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, +abnormalities%22">xlink "> abnormalities, using spatial transcriptomics, several days apart, novel &# 8221, highlight &# 8220, common congenital defects, genomic data analyses, expression data confirm, arterial valves form, developing heart valves, developing arterial valves, related genes may, differentially expressed genes, mouse atrioventricular valves, arterial valve defects, signalling pathways important, arterial valve development, arterial valves, genes important, developing embryo, data suggests, valve development
الوصف: 3D reconstructions of the aortic valve of wild type and Rbp1 null mutants at E15.5 and P1 placed within the aortic root (grey). WT and Rbp1-/- mutants are matched for orientation. Red = non-coronary leaflet, yellow = left leaflet, green = right leaflet. Orange is a fused non-coronary and left leaflet. At E15.5, three leaflets were seen in the aortic valve of WT at E15.5. In comparison, two leaflets observed in a Rbp1-/- mutant (Mut 1) observed from the right side. In the other mutant (Mut 2) shown, three leaflets were observed although two were fused along the majority of their length. In this latter case, it is clear that the proximal extent of the leaflets is not the same (arrows). Three leaflets are seen in both the WT and Rbp1-/- at P1, although abnormalities in the shape and position of the leaflets are apparent. (TIF)
نوع الوثيقة: still image
اللغة: unknown
Relation: https://figshare.com/articles/figure/3D_reconstructions_of_WT_and_i_Rbp1-_-_i_aortic_valves_in_position_within_the_aortic_root_/24645305
DOI: 10.1371/journal.pgen.1010777.s009
الاتاحة: https://doi.org/10.1371/journal.pgen.1010777.s009
https://figshare.com/articles/figure/3D_reconstructions_of_WT_and_i_Rbp1-_-_i_aortic_valves_in_position_within_the_aortic_root_/24645305
Rights: CC BY 4.0
رقم الانضمام: edsbas.1AA17ACD
قاعدة البيانات: BASE
الوصف
DOI:10.1371/journal.pgen.1010777.s009