التفاصيل البيبلوغرافية
| العنوان: |
Acute Kidney Injury Results in Long-Term Diastolic Dysfunction That Is Prevented by Histone Deacetylase Inhibition |
| المؤلفون: |
Soranno, Danielle E., Kirkbride-Romeo, Lara, Wennersten, Sara A., Ding, Kathy, Cavasin, Maria A., Baker, Peter, Altmann, Christopher, Bagchi, Rushita A., Haefner, Korey R., Steinkühler, Christian, Montford, John R., Keith, Brysen, Gist, Katja M., McKinsey, Timothy A., Faubel, Sarah |
| المساهمون: |
Pediatrics, School of Medicine |
| المصدر: |
PMC |
| بيانات النشر: |
Elsevier |
| سنة النشر: |
2021 |
| المجموعة: |
Indiana University - Purdue University Indianapolis: IUPUI Scholar Works |
| مصطلحات موضوعية: |
Acute kidney injury, Cardiorenal syndrome, Diastolic dysfunction, Histone deacetylase inhibition, Systemic sequelae of kidney disease |
| الوصف: |
Growing epidemiological data demonstrate that acute kidney injury (AKI) is associated with long-term cardiovascular morbidity and mortality. Here, the authors present a 1-year study of cardiorenal outcomes following bilateral ischemia-reperfusion injury in male mice. These data suggest that AKI causes long-term dysfunction in the cardiac metabolome, which is associated with diastolic dysfunction and hypertension. Mice treated with the histone deacetylase inhibitor, ITF2357, had preservation of cardiac function and remained normotensive throughout the study. ITF2357 did not protect against the development of kidney fibrosis after AKI. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
JACC: Basic to Translational Science; Soranno DE, Kirkbride-Romeo L, Wennersten SA, et al. Acute Kidney Injury Results in Long-Term Diastolic Dysfunction That Is Prevented by Histone Deacetylase Inhibition. JACC Basic Transl Sci. 2021;6(2):119-133. Published 2021 Feb 22. doi:10.1016/j.jacbts.2020.11.013; https://hdl.handle.net/1805/29652 |
| الاتاحة: |
https://hdl.handle.net/1805/29652 |
| Rights: |
Attribution-NonCommercial-NoDerivatives 4.0 International ; http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: |
edsbas.1A881BB8 |
| قاعدة البيانات: |
BASE |