Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release

التفاصيل البيبلوغرافية
العنوان:	Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release
المؤلفون:	Kittel, Robert J., Wichmann, Carolin, Rasse, T. M., Fouquet, W., Schmidt, Manuela, Schmid, Andreas, Wagh, D. A., Pawlu, C., Kellner, Robert R., Willig, Katrin I., Hell, Stefan, Buchner, E., Heckmann, M., Sigrist, Stephan J.
المساهمون:	Kittel, Robert J., Wichmann, Carolin, Rasse, T. M., Fouquet, W., Schmidt, Manuela, Schmid, Andreas, Wagh, D. A., Pawlu, C., Kellner, Robert R., Willig, Katrin I., Hell, Stefan, Buchner, E., Heckmann, M., Sigrist, Stephan J.
سنة النشر:	2006
المجموعة:	Georg-August-Universität Göttingen: GoeScholar
الوصف:	The molecular organization of presynaptic active zones during calcium influx - triggered neurotransmitter release is the focus of intense investigation. The Drosophila coiled-coil domain protein Bruchpilot (BRP) was observed in donut-shaped structures centered at active zones of neuromuscular synapses by using subdiffraction resolution STED ( stimulated emission depletion) fluorescence microscopy. At brp mutant active zones, electron-dense projections (T-bars) were entirely lost, Ca2+ channels were reduced in density, evoked vesicle release was depressed, and short-term plasticity was altered. BRP-like proteins seem to establish proximity between Ca2+ channels and vesicles to allow efficient transmitter release and patterned synaptic plasticity.
نوع الوثيقة:	article in journal/newspaper
اللغة:	English
ردمك:	978-0-00-237628-0 0-00-237628-8
Relation:	https://resolver.sub.uni-goettingen.de/purl?gro-2/1229; 000237628800045; 3143688
DOI:	10.1126/science.1126308
الاتاحة:	https://resolver.sub.uni-goettingen.de/purl?gro-2/1229 https://doi.org/10.1126/science.1126308
Rights:	info:eu-repo/semantics/openAccess
رقم الانضمام:	edsbas.1A3A92DC
قاعدة البيانات:	BASE

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الوصف
ردمك:	9780002376280 0002376288
DOI:	10.1126/science.1126308