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MICA*A4 protects against ulcerative colitis, whereas MICA*A5.1 is associated with abscess formation and age of onset.

التفاصيل البيبلوغرافية
العنوان: MICA*A4 protects against ulcerative colitis, whereas MICA*A5.1 is associated with abscess formation and age of onset.
المؤلفون: Martinez-Chamorro, A, Moreno, A, Gómez-García, M, Cabello, M J, Martin, J, Lopez-Nevot, M Á
سنة النشر: 2016
المجموعة: Sistema Sanitario Público de Andalucía (SSPA): Repositorio
مصطلحات موضوعية: MHC, autoimmunity, cell surface molecules, inflammation, molecular biology, Abscess, Adult, Age of Onset, Alleles, Amino Acid Sequence, Case-Control Studies, Colitis, Ulcerative, Female, Gene Expression, Gene Frequency, Genetic Predisposition to Disease, HLA-B27 Antigen, HLA-B52 Antigen, Haplotypes, Histocompatibility Antigens Class I, Humans, Male, Middle Aged, Models, Molecular, Odds Ratio, Polymorphism, Genetic, Protein Domains
الوصف: Ulcerative colitis (UC) is one of the two major forms of inflammatory bowel disease, the aetiology of which remains unknown. Several studies have demonstrated the genetic basis of disease, identifying more than 130 susceptibility loci. The major histocompatibility complex class I chain-related gene A (MICA) is a useful candidate to be involved in UC pathogenesis, because it could be important in recognizing the integrity of the epithelial cell and its response to stress. The aim of this study was to analyse the relationship between polymorphisms in the transmembrane domain of MICA and susceptibility to develop UC. A total of 340 patients with UC and 636 healthy controls were genotyped for MICA transmembrane polymorphism using a polymerase chain reaction (PCR) combined with fluorescent technology. Different MICA alleles were determined depending on the PCR product size. The allele MICA*A4 was less frequent in patients than in controls (P = 0·003; OR = 0·643), and this protective role is higher when it forms haplotype with B*27 (P = 0·002; OR = 0·294). The haplotype HLA-B*52/MICA*A6 was also associated with UC [P = 0·001; odds ratio (OR) = 2·914]. No other alleles, genotypes or haplotypes were related with UC risk. Moreover, MICA*A5.1 is associated independently with abscesses (P = 0·002; OR = 3·096) and its frequency is lower in patients diagnosed between ages 17 and 40 years (P = 0·007; OR = 0·633), meaning an extreme age on onset. No association with location, extra-intestinal manifestations or need for surgery was found.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 1365-2249
Relation: http://hdl.handle.net/10668/9891; PMC4872378; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872378; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872378/pdf
DOI: 10.1111/cei.12786
الاتاحة: http://hdl.handle.net/10668/9891
https://doi.org/10.1111/cei.12786
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872378
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872378/pdf
Rights: open access
رقم الانضمام: edsbas.1A1252A
قاعدة البيانات: BASE
الوصف
تدمد:13652249
DOI:10.1111/cei.12786