Academic Journal
Improved reconstruction stability for chemical shift encoded hyperpolarized 13 C magnetic resonance spectroscopic imaging using k‐t spiral acquisitions
| العنوان: | Improved reconstruction stability for chemical shift encoded hyperpolarized 13 C magnetic resonance spectroscopic imaging using k‐t spiral acquisitions |
|---|---|
| المؤلفون: | Macdonald, Erin B., Barton, Gregory P., Cox, Benjamin L., Johnson, Kevin M., Strigel, Roberta M., Fain, Sean B. |
| المساهمون: | National Institute of Diabetes and Digestive and Kidney Diseases, Department of Radiology, University of Wisconsin-Madison, American Association of Physicists in Medicine, National Center for Advancing Translational Sciences, Radiological Society of North America, Research and Development, GE Healthcare |
| المصدر: | Magnetic Resonance in Medicine ; volume 84, issue 1, page 25-38 ; ISSN 0740-3194 1522-2594 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2019 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Purpose A multiecho, field of view (FOV)‐oversampled k‐t spiral acquisition and direct iterative decomposition of water and fat with echo asymmetry and least‐squares estimation reconstruction is demonstrated to improve the stability of hyperpolarized 13 C magnetic resonance spectroscopic imaging (MRSI) in the presence of signal ambiguities attributed to low‐SNR (signal‐to‐noise‐ratio) species, local uncertainties in metabolite peaks, and echo‐to‐echo signal inconsistencies. Theory k‐t spiral acquisitions redistribute readout points to be more densely spaced radially in k‐space by acquiring an FOV and matrix that are oversampled by η . These more densely spaced spiral turns constitute effective intraspiral echoes and can supplement conventional interspiral echoes to improve spectral separation and reduce spectral cross‐talk to better resolve 13 C‐labeled species for spectroscopic imaging. Methods Digital simulations and imaging phantom experiments were performed for a range of interspiral echo spacings and η using multiecho, k‐t spiral acquisitions. Image spectral cross‐talk artifacts were evaluated both qualitatively and quantitatively as the percent error in measured metabolite ratios. In vivo murine experiments evaluated the feasibility of multiecho, k‐t spiral [1‐ 13 C]pyruvate MRSI to reduce spectral cross‐talk for 3 scenarios of different expected reconstruction stability. Results Digital simulations and imaging phantom experiments both demonstrated reduced or comparable image spectral cross‐talk and percent errors in measured metabolite ratios with increasing η and better choices of echo spacings. In vivo images displayed markedly reduced spectral cross‐talk in lactate images acquired with η = 7 versus η = 1. Conclusion The precision of hyperpolarized 13 C metabolic imaging and quantification in the presence of low‐SNR species, local uncertainties in metabolite resonances, and echo‐to‐echo signal inconsistencies can be improved with the use of FOV‐oversampled k‐t spiral acquisitions. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/mrm.28122 |
| الاتاحة: | http://dx.doi.org/10.1002/mrm.28122 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmrm.28122 https://onlinelibrary.wiley.com/doi/pdf/10.1002/mrm.28122 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/mrm.28122 https://onlinelibrary.wiley.com/doi/am-pdf/10.1002/mrm.28122 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#am ; http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.19A9A506 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/mrm.28122 |
|---|