التفاصيل البيبلوغرافية
| العنوان: |
DataSheet1_Abietane-Type Diterpenoids From Nepeta bracteata Benth. and Their Anti-Inflammatory Activity.pdf |
| المؤلفون: |
Er-Lan Yang, Yong Hou, Guo-Xu Ma, Lin-Jun Zou, Xu-Dong Xu, Hai-Feng Wu, Jun-Shan Yang, Hong-Wan Wei, Cong-Zhao Fan, Zhao-Cui Sun, Lei-Ling Shi |
| سنة النشر: |
2022 |
| المجموعة: |
Frontiers: Figshare |
| مصطلحات موضوعية: |
Biochemistry, Environmental Chemistry, Geochemistry, Organic Chemistry, Inorganic Chemistry, Nuclear Chemistry, Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics), Medical Biochemistry and Metabolomics not elsewhere classified, Food Chemistry and Molecular Gastronomy (excl. Wine), Analytical Biochemistry, Cell Neurochemistry, Enzymes, Electroanalytical Chemistry, Analytical Chemistry not elsewhere classified, Organic Green Chemistry, Physical Organic Chemistry, Catalysis and Mechanisms of Reactions, Environmental Chemistry (incl. Atmospheric Chemistry), abietane-type diterpenoids, ursane-type triterpenoid, Nepeta bracteata Benth, anti-inflammatory, drug candidates |
| الوصف: |
Terpenes possess a wide range of structural features and pharmaceutical activities and are promising for drug candidates. With the aim to find bioactive terpene molecules, eight new compounds were isolated from the medicinal plant Nepeta bracteata Benth., including seven new abietane-type diterpenoids (1–7), along with a new ursane-type triterpenoid(8). The structures of compounds 1–8 were elucidated through the detailed spectroscopic analyses of their 1D and 2D NMR and MS data, and the absolute configurations of compounds 1–7 were determined by comparing their experimental and calculated ECD spectra. Compound 1 was a novel degraded carbon diterpene with the disappearing of methyl signal at C-19, while compound 7 possessed a new norabietane-type diterpenoid carbon skeleton with the presence of five-membered lactone arising from ring rearrangement. The anti-inflammatory of all obtained isolates were evaluated on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and the results of anti-inflammatory activity screening showed that compared with the LPS model group, all compounds were significantly down-regulation the TNF-α inflammatory factor at the specific concentration, except for compound 6. |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/dataset/DataSheet1_Abietane-Type_Diterpenoids_From_Nepeta_bracteata_Benth_and_Their_Anti-Inflammatory_Activity_pdf/20220729 |
| DOI: |
10.3389/fchem.2022.944972.s001 |
| الاتاحة: |
https://doi.org/10.3389/fchem.2022.944972.s001
https://figshare.com/articles/dataset/DataSheet1_Abietane-Type_Diterpenoids_From_Nepeta_bracteata_Benth_and_Their_Anti-Inflammatory_Activity_pdf/20220729 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.19824BF |
| قاعدة البيانات: |
BASE |