Academic Journal
Pomegranate juice ameliorates dopamine release and behavioral deficits in a rat model of parkinson’s disease
| العنوان: | Pomegranate juice ameliorates dopamine release and behavioral deficits in a rat model of parkinson’s disease |
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| المؤلفون: | KUJAWSKA, M., JOURDES, Michael, WITUCKI, L., KARAZNIEWICZ-LADA, M., SZULC, M., GORSKA, A., MIKOLAJCZAK, P.L., TEISSEDRE, Pierre Louis, JODYNIS-LIEBERT, J. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pomegranate juice, Urolithin, Ellagitannins, Dopamine, Olfactory impairment, ?-synuclein, Non-motor symptoms, Motor symptoms, Parkinson’s disease, Sciences du Vivant [q-bio]/Biologie végétale |
| الوصف: | Pomegranate juice (PJ) is a rich source of ellagitannins (ETs), precursors of colonic metabolite urolithin A, which are believed to contribute to pomegranate’s neuroprotective effect. While many experimental studies involving PJ’s role in Alzheimer’s disease and hypoxic-ischemic brain injury have been conducted, our knowledge of pomegranate’s effects against Parkinson’s disease (PD) is very limited. Previously, we have reported that PJ treatment improved postural stability, which correlated well with enhancement of neuronal survival, protection against oxidative damage, and ?-synuclein aggregation. Since olfactory and motor deficits are typical symptoms of PD, in this study, we aimed to investigate the capability of PJ to protect against olfactory, motoric, and neuro-chemical alterations. To evaluate its efficiency, Wistar rats were given a combined treatment with ROT (1.3 mg/kg b.w./day, s.c.) and PJ (500 mg/kg/day, p.o.) for 35 days. After this, we assessed the olfactory discrimination index (DI) and vertical and horizontal activities as well as levels of dopamine and its main metabolite 3,4-Dihydroxyphenylacetic acid (DOPAC) in the dissected midbrain of animals. Our findings provide the first evidence that PJ treatment protects against ROT-induced DA depletion in the midbrain, which correlates well with improved olfactory function and vertical activity as well as with the presence of urolithin A in the brain. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://oskar-bordeaux.fr/handle/20.500.12278/124002 |
| DOI: | 10.3390/brainsci11091127 |
| الاتاحة: | https://oskar-bordeaux.fr/handle/20.500.12278/124002 https://hdl.handle.net/20.500.12278/124002 https://doi.org/10.3390/brainsci11091127 |
| Rights: | Attribution 3.0 United States ; open ; http://creativecommons.org/licenses/by/3.0/us/ ; CC BY |
| رقم الانضمام: | edsbas.1966A4B6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/brainsci11091127 |
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