Academic Journal
Level function levels and oxidative stress markers in patients with multidrug-resistant tuberculosis in the Brazilian Amazon
| العنوان: | Level function levels and oxidative stress markers in patients with multidrug-resistant tuberculosis in the Brazilian Amazon |
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| المؤلفون: | C. A. Sales, M. C. F. Pinto-Silva, J. G. Bardález-Rivera, C. A. Abreu-Alberio, L. W. P. Sena, J. L. F. Vieira |
| المصدر: | Brazilian Journal of Biology, Vol 83 (2024) |
| بيانات النشر: | Instituto Internacional de Ecologia |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | tuberculosis, multidrug-resistant tuberculosis, oxidation enzymes, liver markers and levofloxacin, Science, Biology (General), QH301-705.5, Zoology, QL1-991, Botany, QK1-989 |
| الوصف: | This study aimed to correlate the values of liver markers with oxidative stress markers in patients with multidrug-resistant tuberculosis in the Brazilian Amazon. A total of 30 patients from the Tuberculosis clinic of a referral hospital were admitted to the study. Whole blood samples were collected for analysis of liver enzyme values and oxidative stress markers by spectrophotometry. The prevalence was male (60%) and the 18-29 age group was the most affected. Patients with multidrug-resistant tuberculosis presented catalase values with a median equal to 6.94 U/gHb and for glutathione, the median was equal to 14.76 µg∕ml. As for the values of liver enzymes (AST, ALT, Gamma-GT and Alkaline phosphatase) the patients had medians equal to 60.50 (U/L); 80 (U/L); 54 (U/L); and 100 (U/L) respectively (p<0.0001). The results suggest a hepatotoxic effect of the drug, which recommends further studies with a larger number of samples in order to investigate the predictors of liver damage in patients with multidrug-resistant tuberculosis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1678-4375 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842023000101073&lng=en&tlng=en; http://www.scielo.br/pdf/bjb/v83/1519-6984-bjb-83-e272512.pdf; https://doaj.org/toc/1678-4375; https://doaj.org/article/bf0786ba3d3d48fc9aabd4526be70c87 |
| DOI: | 10.1590/1519-6984.272512 |
| الاتاحة: | https://doi.org/10.1590/1519-6984.272512 https://doaj.org/article/bf0786ba3d3d48fc9aabd4526be70c87 |
| رقم الانضمام: | edsbas.1941B9C9 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16784375 |
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| DOI: | 10.1590/1519-6984.272512 |